NLRP10

Gene Symbol	NLRP10
Entrez Gene	338322
Alt Symbol	CLR11.1, NALP10, NOD8, PAN5, PYNOD
Species	Human
Gene Type	protein-coding
Description	NLR family, pyrin domain containing 10
Other Description	NACHT, LRR and PYD domains-containing protein 10|NACHT, leucine rich repeat and PYD containing 10|nucleotide-binding oligomerization domain protein 8|nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 10
Swissprots	Q86W26 Q2M3C4 Q6JGT0
Accessions	EAW68640 Q86W26 AY154465 AAO18161 AY489192 AAS67384 BC104957 AAI04958 BK001110 DAA01243 XM_011520043 XP_011518345 XM_011546581 XP_011544883 XM_011548868 XP_011547170 NM_176821 NP_789791
Function	Inhibits autoprocessing of CASP1, CASP1-dependent IL1B secretion, PYCARD aggregation and PYCARD-mediated apoptosis but not apoptosis induced by FAS or BID. Displays anti-inflammatory activity. Plays a role in adaptive immunity through control of dendritic cell-mediated transport of antigen to the lymph nodes from peripheral sites. Required for immunity against C.albicans infection. Involved in the innate immune response by contributing to proinflammatory cytokine release in response to invasive bacterial infection. {ECO:0000269|PubMed:15096476, ECO:0000269|PubMed:20393137, ECO:0000269|PubMed:22672233}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:22672233}. Cell membrane {ECO:0000269|PubMed:22672233}. Note=Cytoplasmic protein which is recruited to the cell membrane by NOD1 following invasive bacterial infection.
Tissue Specificity	Highly expressed in basal and suprabasal epidermal cell layers with lower levels in dermal fibroblast cells (at protein level). Widely expressed with highest levels in heart, brain and skeletal muscle. Also expressed in liver, colon, dermis and epidermis. Little expression detected in myeloid cells or peripheral blood mononuclear cells. {ECO:0000269|PubMed:15096476, ECO:0000269|PubMed:22672233}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

NOD8 / NLRP10 Antibody Blocking Peptide - LS-E2468 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NOD8 / NLRP10 Blocking Peptide - LS-E27872 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NOD8 / NLRP10 Antibody Blocking Peptide - LS-E30995 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

NLRP10/Pynod/NALP10 Blocking Peptide - NBP1-76291PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

NLRP10-Antibody-C-term-Blocking-peptide - BP13494b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

NALP10 Peptide - GTX85154-PEP from GeneTex Category Peptide Prices $149.00 Sizes 50 μg Species Human

NLRP10 control peptide - AP26266CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

NALP10 Peptide - 5967P from ProSci Category Peptide Species Human

NLRP10 fusion protein - ag20697 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human NACHT, LRR and PYD domains-containing protein 10(NLRP10) - CSB-YP773044HU CSB-EP773044HU CSB-BP773044HU CSB-MP773044HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

NLRP10 - TP311215 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

NLRP10/Pynod/NALP10 Recombinant Protein Antigen - NBP1-85557PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

NLRP10/Pynod/NALP10 Recombinant Protein Antigen - NBP1-85556PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

NLRP10 Peptide, Human - M34GP10433H from Creative Peptides Category Peptide Source Synthetic. Species Human

NLRP10 fusion protein - Ag26402 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

NLRP10 fusion protein - Ag26416 from Proteintech Group Category Protein Source E. coli -derived, PET28a Species Human

NACHT, LRR and PYD domains-containing protein 10 (NLRP10), Recombinant Protein - MBS1330087 from MyBioSource Category Protein Prices $1,455.00, $1,455.00, $1,685.00, $1,685.00, $2,470.00, $2,470.00, $2,915.00, $2,915.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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