NFKB1

Gene Symbol NFKB1
Entrez Gene 4790
Alt Symbol EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50
Species Human
Gene Type protein-coding
Description nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
Other Description DNA binding factor KBF1|DNA-binding factor KBF1|NF-kappabeta|nuclear factor NF-kappa-B p105 subunit|nuclear factor NF-kappa-B p50 subunit|nuclear factor kappa-B DNA binding subunit
Swissprots Q68D84 Q8N4X7 A8K5Y5 B3KVE8 P19838 Q9NZC0 Q86V43
Accessions AAF35232 AAO30127 CAB94757 CCA94577 CDH63539 EAX06134 EAX06135 EAX06136 P19838 AI076882 AK122850 BAG53760 AK291450 BAF84139 BC033210 AAH33210 BC051765 AAH51765 BQ023914 CR749522 CAH18336 EU446640 ABZ92169 M55643 AAA36361 M58603 AAA36360 XM_011532006 XP_011530308 XM_011532007 XP_011530309 XM_011532008 XP_011530310 XM_011532009 XP_011530311 NM_001165412 NP_001158884 NM_003998 NP_003989
Function NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with ot
Subcellular Location Nucleus. Cytoplasm. Note=Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B).
Top Pathways Osteoclast differentiation, PI3K-Akt signaling pathway, Viral carcinogenesis, Legionellosis, Epstein-Barr virus infection

Phospho-NF-κB p105 (Ser933) (18E6) Rabbit mAb - 4806 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 18E6
Western blot analysis of extracts from Vero cells, untreated or treated with TNF-α #2169 (20 ng/ml) for the times indicated, using Phospho-NF-κB p105 (Ser933) (18E6) Rabbit mAb #4806 (upper) and NF-κB p105/p50 Antibody #3035 (lower).

Phospho-NF-κB p105 (Ser933) (178F3) Rabbit mAb (IHC Specific) - 4808 from Cell Signaling Technology

Prices $287.00
Sizes 50 µl (50 sections)
Host Rabbit
Clonality Monoclonal
Clone 178F3
Immunohistochemical analysis of paraffin-embedded human breast carcinoma, using Phospho-NF-kappaB p105 (Ser933) (178F3) Rabbit mAb (IHC Specific) in the presence of control peptide (left) or Phospho-NF-kappaB p105 (Ser933) Blocking Peptide #1021 (right).

NF-κB1 p105/p50 (D7H5M) Rabbit mAb - 12540 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D7H5M
Western blot analysis of extracts from various cell lines using NF-κB1 p105/p50 (D7H5M) Rabbit mAb.

NF-κB1 p105/p50 Antibody - 3035 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from Vero cells, untreated or treated with TNF-α #2169 (20 ng/ml) for the times indicated, using Phospho-NF-κB p105 (Ser933) (18E6) Rabbit mAb #4806 (upper) and NF-κB p105/p50 Antibody #3035 (lower).

NF-κB1 p105/p50 (5D10D11) Mouse mAb - 13681 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Mouse
Clonality Monoclonal
Clone 5D10D11
Western blot analysis of extracts from various cell lines using NF-κB1 p105/p50 (5D10D11) Mouse mAb.

NF-κB1 p105 Antibody - 4717 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from THP-1 cells, differentiated with TPA (#9905, 80 nM for 24 h) and treated with 1 μg/ml LPS for the indicated times, using NF-κB1 p105 Antibody.

Phospho-NF-kappaB p105 (Ser933) Antibody - 4884 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal

Phospho-NF-KappaB p105 (Ser927) Antibody - 3038 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal

NFκB p50 (D-6) - sc-166588 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
NFκB p50 (D-6): sc-166588. Western blot analysis of NFκB p50 expression in K-562 whole cell lysate.

NFκB p50 (H-119) - sc-7178 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
ChIP analysis of cofactor occupancy dynamics on the <i>IL</i>-<i>8</i> promoter in 293 cells in response to IL-1β treatment. Antibodies tested include NFκB p50 (C-19): sc-1190, NFκB p50 (E-10): sc-8414, NFκB p50 (H-119): sc-7178, NFκB p65 (C-20): sc-372, NFκB p65 (A): sc-109, NFκB p65 (H-286): sc-7151, CBP (A-22): sc-369, CBP (C-1): sc-7300, CBP (C-20): sc-583, CBP (451): sc-1211, p300 (C-20): sc-sc-585, p300 (N-15): sc-584, p300 (H-272): sc-8981. Data kindly provided by M.G. Rosenfeld and reproduced with permission from Baek <i>et al</i>., Cell 2002, 110: 55-67.

NFκB p50 (NLS) - sc-114 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
NFκB p50 (NLS): sc-114. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human breast tumor showing nuclear and cytoplasmic staining.

NFκB p50 (E-10) - sc-8414 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
NFκB p50 (E-10): sc-8414. Immunofluorescence staining of methanol-fixed K-562 cells showing nuclear localization using indirect FITC (A) staining and HeLa cells showing cytoplasmic localization using direct Alexa Fluor 488 (B) staining.

NFκB p50 (C-19) - sc-1190 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
NFκB p50 (C-19): sc-1190. Western blot analysis of NFκB p50 and its precursor, p105, in CTLL-2 whole cell lysate.

NFκB p50 (N-19) - sc-1191 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
NFκB p50 (N-19): sc-1191. Western blot analysis of NFκB p50 and p105 expression in A-431 whole cell lysate.

NFκB p50 (4D1) - sc-53744 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
NFκB p50 (4D1): sc-53744. Western blot analysis of NFκB p50 expression in IFNγ-treated HeLa (A) and A-431 (B) whole cell lysates and PC-3 (C) and SW480 (D) nuclear extracts.

p-NFκB p50 (Ser 337) - sc-101744 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
p-NFκB p50 (Ser 337): sc-101744. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human breast carcinoma tissue showing cytoplasmmic and nuclear staining.

p-NFκB p50 (Ser 337) - sc-33022 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
p-NFκB p50 (Ser 337): sc-33022. Western blot analysis of NFκB p50 phosphorylation in 293T (A) and K-562 (B) whole cell lysates.

p-NFκB p50 (Ser 893) - sc-101745 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
p-NFκB p50 (Ser 893): sc-101745. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human breast carcinoma tissue showing cytoplasmmic and nuclear staining.

p-NFκB p50 (Ser 907) - sc-101746 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
p-NFκB p50 (Ser 907): sc-101746. Western blot analysis of phosphorylated NFκB p50 expression in untreated (A) and TNF-α treated (B) HeLa whole cell lysates.

p-NFκB p50 (Ser 932) - sc-101747 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
Western blot analysis of NFκB p50 phosphorylation in untreated (A,D), calyculin A treated (B,E) and calyculin A and lambda protein phosphatase treated (C,F) HeLa whole cell lysates. Antibodies tested include p-NFκB p50 (Ser 932): sc-101747 (A,B,C) and NFκB p50 (E-10): sc-8414 (D,E,F).

p-NFκB p50 (Ser 927) - sc-101756 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
p-NFκB p105/p50 (Ser 927): sc-101756. Western blot analysis of NFκB p105/p50 expression in untreated (A) and TNFα+Calcyclin A-treated (B) HT-29 whole cell lysates.

Anti-NFkB p105 / p50 (phospho S337) antibody - ab28849 from Abcam

Prices $379.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Ab28849, at a dilution of 1/50, staining p105 in paraffin embedded human breast carcinoma tissue by Immunohistochemistry.

Anti-NFkB p105 / p50 (phospho S337) antibody - ab194729 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunofluorescent analysis of methanol fixed HeLa cells labeling NFkB p105 / p50 (phospho S337) with ab194729 at 1/100.

Anti-NFkB p105 / p50 (phospho S893) antibody - ab28850 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Ab28850, at a dilution of 1/50, staining p105 in paraffin embedded human breast carcinoma tissue by Immunohistochemistry. Left image: untreated. Right image: the same antibody preincubated with synthesized phosphopeptide.

Anti-NFkB p105 / p50 (phospho S893) antibody - ab194931 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human breast carcinoma tissue labeling NFkB p105 / p50 with ab194931 at 1/50 dilution.
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