NFKB1

Gene Symbol	NFKB1
Entrez Gene	4790
Alt Symbol	EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50
Species	Human
Gene Type	protein-coding
Description	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
Other Description	DNA binding factor KBF1|DNA-binding factor KBF1|NF-kappabeta|nuclear factor NF-kappa-B p105 subunit|nuclear factor NF-kappa-B p50 subunit|nuclear factor kappa-B DNA binding subunit
Swissprots	Q68D84 Q8N4X7 A8K5Y5 B3KVE8 P19838 Q9NZC0 Q86V43
Accessions	AAF35232 AAO30127 CAB94757 CCA94577 CDH63539 EAX06134 EAX06135 EAX06136 P19838 AI076882 AK122850 BAG53760 AK291450 BAF84139 BC033210 AAH33210 BC051765 AAH51765 BQ023914 CR749522 CAH18336 EU446640 ABZ92169 M55643 AAA36361 M58603 AAA36360 XM_011532006 XP_011530308 XM_011532007 XP_011530309 XM_011532008 XP_011530310 XM_011532009 XP_011530311 NM_001165412 NP_001158884 NM_003998 NP_003989
Function	NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with ot
Subcellular Location	Nucleus. Cytoplasm. Note=Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B).
Top Pathways	Osteoclast differentiation, PI3K-Akt signaling pathway, Viral carcinogenesis, Legionellosis, Epstein-Barr virus infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human NFkB p105 / p50 full length protein - ab114185 from Abcam Category Protein Source Wheat germ Species Human

Human NFkB p105 / p50 protein fragment - ab112327 from Abcam Category Protein Source Wheat germ Species Human

Human NFkB p105 / p50 protein fragment - ab134884 from Abcam Category Protein Source E. coli Species Human

NFkB p105 / p50 peptide - ab8006 from Abcam Category Peptide

NFkB p105 / p50 peptide - ab7550 from Abcam Category Peptide

NFKB1 / NF-Kappa-B Antibody Blocking Peptide - LS-E6390 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NFKB1 / NF-Kappa-B Antibody Blocking Peptide - LS-E13800 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human NFkB p105/p50 Protein - H00004790-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human NFkB p105/p50 Protein - H00004790-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

NFkB p105/p50 Peptide - NBP1-96926 from Novus Biologicals Category Peptide Prices $169.00 Sizes 50 µg

NFKBp105-Antibody-C-term-S933-Blocking-Peptide - BP19121b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

NFKB1-Antibody-S903-Blocking-Peptide - BP1980b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

NFkB p50 peptide - GTX28006 from GeneTex Category Peptide Prices $179.00 Sizes 100 μg Species Human

NFkB p50 peptide - GTX27550 from GeneTex Category Peptide Prices $179.00 Sizes 50 μg Species Human

Recombinant human Nuclear factor NF-kappa-B p105 subunit protein (OPCA00867) - OPCA00867 from Aviva Systems Biology Category Protein Prices $220.00 Sizes 50 µg Species Human

Human NFKB1 protein - orb245461 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

NFKB1 peptide - orb217664 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Drosophila, Cat

NFkB p105 Blocking Peptide - 33R-10986 from Fitzgerald Category Peptide Prices $145.00 Sizes 50 µg

NFkB p105 Blocking Peptide - 33R-10567 from Fitzgerald Category Peptide Prices $295.00 Sizes 50 µg

NFkB p105 subunit protein - 30R-3188 from Fitzgerald Category Protein Prices $210.00 Sizes 50 µg Source E.coli

NFkB p50 Blocking Peptide - 33R-10470 from Fitzgerald Category Peptide Prices $295.00 Sizes 50 µg

NFkB p50 Blocking Peptide - 33R-10722 from Fitzgerald Category Peptide Prices $145.00 Sizes 50 µg

NFKB1 Blocking Peptide - 33R-5351 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Human Nuclear Factor Kappa B Protein - abx068338 from Abbexa Category Protein Source E.coli Species Human

NF-kB p105 / p50 - H00004790-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

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