NFKB1

Gene Symbol	NFKB1
Entrez Gene	4790
Alt Symbol	EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50
Species	Human
Gene Type	protein-coding
Description	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
Other Description	DNA binding factor KBF1|DNA-binding factor KBF1|NF-kappabeta|nuclear factor NF-kappa-B p105 subunit|nuclear factor NF-kappa-B p50 subunit|nuclear factor kappa-B DNA binding subunit
Swissprots	Q68D84 Q8N4X7 A8K5Y5 B3KVE8 P19838 Q9NZC0 Q86V43
Accessions	AAF35232 AAO30127 CAB94757 CCA94577 CDH63539 EAX06134 EAX06135 EAX06136 P19838 AI076882 AK122850 BAG53760 AK291450 BAF84139 BC033210 AAH33210 BC051765 AAH51765 BQ023914 CR749522 CAH18336 EU446640 ABZ92169 M55643 AAA36361 M58603 AAA36360 XM_011532006 XP_011530308 XM_011532007 XP_011530309 XM_011532008 XP_011530310 XM_011532009 XP_011530311 NM_001165412 NP_001158884 NM_003998 NP_003989
Function	NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with ot
Subcellular Location	Nucleus. Cytoplasm. Note=Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B).
Top Pathways	Osteoclast differentiation, PI3K-Akt signaling pathway, Viral carcinogenesis, Legionellosis, Epstein-Barr virus infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

NFKB1 293T Cell Transient Overexpression Lysate(Denatured) - H00004790-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

NFKB1 overexpression lysate - LY418264 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

NFKB1 293 Cell Lysate - 408526 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

NFkB p105/p50 Overexpression Lysate (Denatured) - H00004790-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

NFkB p105/p50 Overexpression Lysate (Native) - NBL1-13619 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

NFκB p50 (h): 293T Lysate - sc-116112 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

NFKB1 Over-expression Lysate Product - GWB-A596F0 from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

Panoply™ Human NFKB1 Knockdown Stable Cell Line - CSC-DC010341 from Creative biogene Category Cell Line Species Human

Human NFKB1 Knockout Cell Line-HeLa - CSC-RT0690 from Creative biogene Category Cell Line Species Human

NFKB1 KO Cell Lysate-HeLa - CLKO-0195 from Creative biogene Category Cell Lysate

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