| Gene Symbol | NFKB1 |
|---|---|
| Entrez Gene | 4790 |
| Alt Symbol | EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50 |
| Species | Human |
| Gene Type | protein-coding |
| Description | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
| Other Description | DNA binding factor KBF1|DNA-binding factor KBF1|NF-kappabeta|nuclear factor NF-kappa-B p105 subunit|nuclear factor NF-kappa-B p50 subunit|nuclear factor kappa-B DNA binding subunit |
| Swissprots | Q68D84 Q8N4X7 A8K5Y5 B3KVE8 P19838 Q9NZC0 Q86V43 |
| Accessions | AAF35232 AAO30127 CAB94757 CCA94577 CDH63539 EAX06134 EAX06135 EAX06136 P19838 AI076882 AK122850 BAG53760 AK291450 BAF84139 BC033210 AAH33210 BC051765 AAH51765 BQ023914 CR749522 CAH18336 EU446640 ABZ92169 M55643 AAA36361 M58603 AAA36360 XM_011532006 XP_011530308 XM_011532007 XP_011530309 XM_011532008 XP_011530310 XM_011532009 XP_011530311 NM_001165412 NP_001158884 NM_003998 NP_003989 |
| Function | NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with ot |
| Subcellular Location | Nucleus. Cytoplasm. Note=Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B). |
| Top Pathways | Osteoclast differentiation, PI3K-Akt signaling pathway, Viral carcinogenesis, Legionellosis, Epstein-Barr virus infection |