Gene Symbol | RASSF10 |
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Entrez Gene | 644943 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | Ras association (RalGDS/AF-6) domain family (N-terminal) member 10 |
Other Description | ras association domain-containing protein 10 |
Swissprots | A6NK89 |
Accessions | A6NK89 BX098487 NM_001080521 NP_001073990 |
Subcellular Location | Cytoplasm, cytosol {ECO:0000269|PubMed:20956940}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:20956940}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:20956940}. Note=During interphase, predominantly cytoplasmic, although some nuclear staining in several tumor cell contexts. During prophase, observed at developing centrosomes. Displays persistent localization with centrosomally radiating microtubule bundles until late telophase. Associates with spindle poles particularly during metaphase and anaphase before relocating back to the cytoplasm. |
Tissue Specificity | Expressed in brain. Tends to be down-regulated in astrocytic gliomas due to promoter methylation. Methylation occurs early in gliomagenesis and the extent of methylation parallels with higher glioma grades, so that methylation is observed in close to 70% WHO grade IV primary glioblastomas, but not in grade I astrocytomas. {ECO:0000269|PubMed:20956940}. |
RASSF10 CRISPR/Cas9 KO Plasmid (h) - sc-410463 from Santa Cruz Biotechnology
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RASSF10 HDR Plasmid (h) - sc-410463-HDR from Santa Cruz Biotechnology
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RASSF10 Double Nickase Plasmid (h) - sc-410463-NIC from Santa Cruz Biotechnology
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RASSF10 Double Nickase Plasmid (h2) - sc-410463-NIC-2 from Santa Cruz Biotechnology
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RASSF10 CRISPR Activation Plasmid (h) - sc-410463-ACT from Santa Cruz Biotechnology
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RASSF10 CRISPR Activation Plasmid (h2) - sc-410463-ACT-2 from Santa Cruz Biotechnology
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RASSF10 Lentiviral Activation Particles (h) - sc-410463-LAC from Santa Cruz Biotechnology
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RASSF10 Lentiviral Activation Particles (h2) - sc-410463-LAC-2 from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN17995 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17995 from Sigma-Aldrich
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RASSF10 siRNA (Human) - CRJ8497 from Cohesion Biosciences
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RASSF10 - MBS8214688 from MyBioSource
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shRNA set against Human RASSF10 (NM_001080521.2) - SHH390156 from Creative biogene
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RASSF10 shRNA Plasmid (Human) - CHJ8497 from Cohesion Biosciences
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RASSF10 miRNA 3'UTR clone - MiUTR4H-TG12298 from Creative biogene
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