| Gene Symbol |
TWISTNB
|
| Entrez Gene |
221830
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
TWIST neighbor
|
| Other Description |
DNA-directed RNA polymerase I subunit RPA43|twist neighbor protein
|
| Swissprots |
A0PJ45 B7Z724 Q3B726
|
| Accessions |
CCQ43008 DAA05732 EAL24277 EAW93714 Q3B726 AK090846 AK301329 BAH13460 BC013179 BC014574 AAH14574 BC056267 BC070358 BC130298 AAI30299 BC130300 AAI30301 HQ258381 ADR83135 NM_001002926 NP_001002926
|
| Function |
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Through its association with RRN3/TIF-IA may be involved in recruitment of Pol I to rDNA promoters.
|
| Subcellular Location |
Nucleus, nucleolus {ECO:0000250}.
|
| Tissue Specificity |
Widely expressed. Expressed in all fetal and adult tissues tested, with highest expression in fetal lung, liver, and kidney, and low expression in all adult tissues. {ECO:0000269|PubMed:12438708}.
|
| Top Pathways |
Purine metabolism, RNA polymerase, Pyrimidine metabolism
|