Gene Symbol | TWISTNB |
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Entrez Gene | 221830 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | TWIST neighbor |
Other Description | DNA-directed RNA polymerase I subunit RPA43|twist neighbor protein |
Swissprots | A0PJ45 B7Z724 Q3B726 |
Accessions | CCQ43008 DAA05732 EAL24277 EAW93714 Q3B726 AK090846 AK301329 BAH13460 BC013179 BC014574 AAH14574 BC056267 BC070358 BC130298 AAI30299 BC130300 AAI30301 HQ258381 ADR83135 NM_001002926 NP_001002926 |
Function | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Through its association with RRN3/TIF-IA may be involved in recruitment of Pol I to rDNA promoters. |
Subcellular Location | Nucleus, nucleolus {ECO:0000250}. |
Tissue Specificity | Widely expressed. Expressed in all fetal and adult tissues tested, with highest expression in fetal lung, liver, and kidney, and low expression in all adult tissues. {ECO:0000269|PubMed:12438708}. |
Top Pathways | Purine metabolism, RNA polymerase, Pyrimidine metabolism |
TWISTNB CRISPR/Cas9 KO Plasmid (h) - sc-415144 from Santa Cruz Biotechnology
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TWISTNB HDR Plasmid (h) - sc-415144-HDR from Santa Cruz Biotechnology
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TWISTNB Double Nickase Plasmid (h) - sc-415144-NIC from Santa Cruz Biotechnology
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TWISTNB Double Nickase Plasmid (h2) - sc-415144-NIC-2 from Santa Cruz Biotechnology
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TWISTNB CRISPR Activation Plasmid (h) - sc-415144-ACT from Santa Cruz Biotechnology
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TWISTNB CRISPR Activation Plasmid (h2) - sc-415144-ACT-2 from Santa Cruz Biotechnology
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TWISTNB Lentiviral Activation Particles (h) - sc-415144-LAC from Santa Cruz Biotechnology
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TWISTNB Lentiviral Activation Particles (h2) - sc-415144-LAC-2 from Santa Cruz Biotechnology
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TWISTNB siRNA (h) - sc-89350 from Santa Cruz Biotechnology
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TWISTNB shRNA Plasmid (h) - sc-89350-SH from Santa Cruz Biotechnology
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TWISTNB shRNA (h) Lentiviral Particles - sc-89350-V from Santa Cruz Biotechnology
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TWISTNB RNAi - H00221830-R01 from Novus Biologicals
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MISSION® esiRNA - EHU030421 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22294 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22294 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR11796 from Sigma-Aldrich
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TWISTNB siRNA (Human) - CRJ6540 from Cohesion Biosciences
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TWISTNB - MBS8226878 from MyBioSource
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shRNA set against Human TWISTNB (NM_001002926.1) - SHH438084 from Creative biogene
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shRNA set against Human TWISTNB(NM_001002926.1) - SHL107580 from Creative biogene
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Human TWISTNB siRNA - orb277041 from Biorbyt
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TWISTNB shRNA Plasmid (Human) - CHJ6540 from Cohesion Biosciences
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TWISTNB miRNA 3'UTR clone - MiUTR1H-10890 from Creative biogene
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