ELFN1
| Gene Symbol | ELFN1 |
|---|---|
| Entrez Gene | 392617 |
| Alt Symbol | PPP1R28 |
| Species | Human |
| Gene Type | protein-coding |
| Description | extracellular leucine-rich repeat and fibronectin type III domain containing 1 |
| Other Description | extracellular leucine-rich repeat and fibronectin type III containing 1|extracellular leucine-rich repeat and fibronectin type-III domain-containing protein 1|protein ELFN1|protein phosphatase 1 regulatory subunit 28|protein phosphatase 1, regulatory subunit 28 |
| Swissprots | P0C7U0 H3BS57 |
| Accessions | EAW87217 P0C7U0 AI962473 BF434584 DR001365 XM_006715725 XP_006715788 XM_006715726 XP_006715789 XM_006715727 XP_006715790 XM_011515397 XP_011513699 XM_011515398 XP_011513700 XM_011515399 XP_011513701 XM_011515400 XP_011513702 XM_011515401 XP_011513703 NM_001128636 NP_001122108 |
| Function | Postsynaptic protein that regulates circuit dynamics in the central nervous system by modulating the temporal dynamics of interneuron recruitment. Specifically present in excitatory synapses onto oriens-lacunosum molecular (OLM) interneurons and acts as a regulator of presynaptic release probability to direct the formation of highly facilitating pyramidal-OLM synapses (By similarity). Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. {ECO:0000250, ECO:0000269|PubMed:19389623}. |
| Subcellular Location | Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell projection, dendrite {ECO:0000250}. Note=Localizes to excitatory synapses onto somatostatin (Sst)-containing oriens-lacunosum moleculare (O-LM) interneurons. {ECO:0000250}. |
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