| Gene Symbol |
ELFN1
|
| Entrez Gene |
392617
|
| Alt Symbol |
PPP1R28
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
extracellular leucine-rich repeat and fibronectin type III domain containing 1
|
| Other Description |
extracellular leucine-rich repeat and fibronectin type III containing 1|extracellular leucine-rich repeat and fibronectin type-III domain-containing protein 1|protein ELFN1|protein phosphatase 1 regulatory subunit 28|protein phosphatase 1, regulatory subunit 28
|
| Swissprots |
P0C7U0 H3BS57
|
| Accessions |
EAW87217 P0C7U0 AI962473 BF434584 DR001365 XM_006715725 XP_006715788 XM_006715726 XP_006715789 XM_006715727 XP_006715790 XM_011515397 XP_011513699 XM_011515398 XP_011513700 XM_011515399 XP_011513701 XM_011515400 XP_011513702 XM_011515401 XP_011513703 NM_001128636 NP_001122108
|
| Function |
Postsynaptic protein that regulates circuit dynamics in the central nervous system by modulating the temporal dynamics of interneuron recruitment. Specifically present in excitatory synapses onto oriens-lacunosum molecular (OLM) interneurons and acts as a regulator of presynaptic release probability to direct the formation of highly facilitating pyramidal-OLM synapses (By similarity). Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. {ECO:0000250, ECO:0000269|PubMed:19389623}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell projection, dendrite {ECO:0000250}. Note=Localizes to excitatory synapses onto somatostatin (Sst)-containing oriens-lacunosum moleculare (O-LM) interneurons. {ECO:0000250}.
|