| Gene Symbol |
NHP2L1
|
| Entrez Gene |
4809
|
| Alt Symbol |
15.5K, FA-1, FA1, NHPX, OTK27, SNRNP15-5, SNU13, SPAG12, SSFA1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)
|
| Other Description |
NHP2-like protein 1|U4/U6.U5 tri-snRNP 15.5 kDa protein|[U4/U6.U5] tri-snRNP 15.5 kD RNA binding protein|high mobility group-like nuclear protein 2 homolog 1|non-histone chromosome protein 2-like 1|small nuclear ribonucleoprotein 15.5kDa (U4/U6.U5)|sperm specific antigen 1
|
| Swissprots |
P55769
|
| Accessions |
CAH05699 CAR82348 EAW60450 EAW60451 EAW60452 EAW60453 P55769 AF091076 AAC72945 AF155235 AAF06959 AK311800 BAG34743 BC005358 AAH05358 BC019282 AAH19282 BC095439 AAH95439 BG164621 BI770951 CF552526 CR456531 CAG30417 CR541725 CAG46526 CU013131 CAK54562 CU013419 CAK54861 D50420 BAA23363 DB021462 XM_011530201 XP_011528503 NM_001003796 NP_001003796 NM_005008 NP_004999
|
| Function |
Binds to the 5'-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding. {ECO:0000269|PubMed:10545122, ECO:0000269|PubMed:17412961}.
|
| Subcellular Location |
Nucleus, nucleolus {ECO:0000269|PubMed:10593953, ECO:0000269|PubMed:12429849, ECO:0000269|Ref.7}. Note=Concentrated in the dense fibrillar component of the nucleolus.
|
| Tissue Specificity |
Ubiquitous.
|
| Top Pathways |
Spliceosome, Ribosome biogenesis in eukaryotes
|
![Western Blot: NHP2L1 Overexpression Lysate (Adult Normal) [NBP2-07801] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for NHP2L1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/15514_NHP2L1%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBP2-07801-img0001.jpg)
![Western Blot: NHP2L1 Overexpression Lysate (Adult Normal) [NBP2-08922] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for NHP2L1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/16107_NHP2L1%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBP2-08922-img0001.jpg)