Gene Symbol | NHP2L1 |
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Entrez Gene | 4809 |
Alt Symbol | 15.5K, FA-1, FA1, NHPX, OTK27, SNRNP15-5, SNU13, SPAG12, SSFA1 |
Species | Human |
Gene Type | protein-coding |
Description | NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae) |
Other Description | NHP2-like protein 1|U4/U6.U5 tri-snRNP 15.5 kDa protein|[U4/U6.U5] tri-snRNP 15.5 kD RNA binding protein|high mobility group-like nuclear protein 2 homolog 1|non-histone chromosome protein 2-like 1|small nuclear ribonucleoprotein 15.5kDa (U4/U6.U5)|sperm specific antigen 1 |
Swissprots | P55769 |
Accessions | CAH05699 CAR82348 EAW60450 EAW60451 EAW60452 EAW60453 P55769 AF091076 AAC72945 AF155235 AAF06959 AK311800 BAG34743 BC005358 AAH05358 BC019282 AAH19282 BC095439 AAH95439 BG164621 BI770951 CF552526 CR456531 CAG30417 CR541725 CAG46526 CU013131 CAK54562 CU013419 CAK54861 D50420 BAA23363 DB021462 XM_011530201 XP_011528503 NM_001003796 NP_001003796 NM_005008 NP_004999 |
Function | Binds to the 5'-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding. {ECO:0000269|PubMed:10545122, ECO:0000269|PubMed:17412961}. |
Subcellular Location | Nucleus, nucleolus {ECO:0000269|PubMed:10593953, ECO:0000269|PubMed:12429849, ECO:0000269|Ref.7}. Note=Concentrated in the dense fibrillar component of the nucleolus. |
Tissue Specificity | Ubiquitous. |
Top Pathways | Spliceosome, Ribosome biogenesis in eukaryotes |
NHPX CRISPR/Cas9 KO Plasmid (h) - sc-410908 from Santa Cruz Biotechnology
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NHPX HDR Plasmid (h) - sc-410908-HDR from Santa Cruz Biotechnology
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NHPX Double Nickase Plasmid (h) - sc-410908-NIC from Santa Cruz Biotechnology
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NHPX Double Nickase Plasmid (h2) - sc-410908-NIC-2 from Santa Cruz Biotechnology
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NHPX CRISPR Activation Plasmid (h) - sc-410908-ACT from Santa Cruz Biotechnology
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NHPX CRISPR Activation Plasmid (h2) - sc-410908-ACT-2 from Santa Cruz Biotechnology
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NHPX Lentiviral Activation Particles (h) - sc-410908-LAC from Santa Cruz Biotechnology
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NHPX Lentiviral Activation Particles (h2) - sc-410908-LAC-2 from Santa Cruz Biotechnology
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NHPX siRNA (h) - sc-75913 from Santa Cruz Biotechnology
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NHPX shRNA Plasmid (h) - sc-75913-SH from Santa Cruz Biotechnology
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NHPX shRNA (h) Lentiviral Particles - sc-75913-V from Santa Cruz Biotechnology
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NHP2L1 RNAi - H00004809-R02 from Novus Biologicals
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NHP2L1 RNAi - H00004809-R01 from Novus Biologicals
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MISSION® esiRNA - EHU093921 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15287 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15287 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07491 from Sigma-Aldrich
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NHP2L1 siRNA (Human) - CRH3193 from Cohesion Biosciences
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shRNA set against Human NHP2L1 (NM_005008.3) - SHH352296 from Creative biogene
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shRNA set against Human NHP2L1(NM_001003796.1) - SHR002632 from Creative biogene
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NHP2L1 shRNA Plasmid (Human) - CHH3193 from Cohesion Biosciences
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NHP2L1 miRNA 3'UTR clone - MiUTR1H-06767 from Creative biogene
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NHP2L1 miRNA 3'UTR clone - MiUTR3H-04051 from Creative biogene
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