| Gene Symbol | Grin2b |
|---|---|
| Entrez Gene | 14812 |
| Alt Symbol | AW490526, GluN2B, NR2B, Nmdar2b |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | glutamate receptor, ionotropic, NMDA2B (epsilon 2) |
| Other Description | GluRepsilon2|N-methyl D-aspartate receptor 2B|N-methyl D-aspartate receptor subtype 2B|glutamate [NMDA] receptor subunit epsilon-2|glutamate receptor ionotropic, NMDA 2B |
| Swissprots | Q01097 Q9DCB2 |
| Accessions | EDL10558 Q01097 AJ459261 CAD30666 AJ459262 CAD30667 AJ459263 CAD30668 AK002963 BAB22483 AK013569 AK163195 BAE37231 BC172745 AAI72745 CF745896 D10651 BAA01498 XM_006505572 XP_006505635 XM_006505573 XP_006505636 XM_006505574 XP_006505637 XM_006505575 XP_006505638 XM_011241219 XP_011239521 XM_011241220 XP_011239522 XM_011241221 XP_011239523 NM_008171 NP_032197 |
| Function | NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death. {ECO:0000269|PubMed:20141836}. |
| Subcellular Location | Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. |
| Top Pathways | Rap1 signaling pathway, Alcoholism, Cocaine addiction, Circadian entrainment, cAMP signaling pathway |