Gene Symbol | B3GALT6 |
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Entrez Gene | 126792 |
Alt Symbol | EDSP2, SEMDJL1, beta3GalT6 |
Species | Human |
Gene Type | protein-coding |
Description | UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6 |
Other Description | GAG GalTII|UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 6|beta-1,3-GalTase 6|beta-1,3-galactosyltransferase 6|beta3Gal-T6|galactosyltransferase II|galactosylxylosylprotein 3-beta-galactosyltransferase |
Swissprots | Q5T7M5 Q96L58 |
Accessions | EAW56269 Q96L58 BC015549 BC041621 BC051719 AAH51719 BC160034 AAI60034 BE249959 BF002665 BG290330 NM_080605 NP_542172 |
Function | Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-linked galactose residue. Has a preference for galactose-beta-1,4-xylose that is found in the linker region of glycosaminoglycans, such as heparan sulfate and chondroitin sulfate. Has no activity towards substrates with terminal glucosamine or galactosamine residues. {ECO:0000269|PubMed:11551958}. |
Subcellular Location | Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:11551958}; Single-pass type II membrane protein {ECO:0000269|PubMed:11551958}. |
Tissue Specificity | Ubiquitous. {ECO:0000269|PubMed:11551958}. |
Top Pathways | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate, Glycosaminoglycan biosynthesis - heparan sulfate / heparin |
β-1,3-Gal-T6 siRNA (h) - sc-78716 from Santa Cruz Biotechnology
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β-1,3-Gal-T6 shRNA Plasmid (h) - sc-78716-SH from Santa Cruz Biotechnology
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β-1,3-Gal-T6 shRNA (h) Lentiviral Particles - sc-78716-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN3800 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3800 from Sigma-Aldrich
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B3GALT6 siRNA (Human) - CRJ4885 from Cohesion Biosciences
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B3GALT6 RNAi - H00126792-R01 from Novus Biologicals
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B3GALT6 - MBS8235563 from MyBioSource
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B3GALT6 - MBS826847 from MyBioSource
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shRNA set against Human B3galt6 (NM_080605.3) - SHH244170 from Creative biogene
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shRNA set against Human B3GALT6(NM_080605.3) - SHG088603 from Creative biogene
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B3GALT6 siRNA - orb219205 from Biorbyt
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Human B3GALT6 siRNA - orb275386 from Biorbyt
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B3GALT6 shRNA Plasmid (Human) - CHJ4885 from Cohesion Biosciences
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B3GALT6 miRNA 3'UTR clone - MiUTR1H-00764 from Creative biogene
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