| Gene Symbol | BPIFA1 |
|---|---|
| Entrez Gene | 51297 |
| Alt Symbol | LUNX, NASG, PLUNC, SPLUNC1, SPURT, bA49G10.5 |
| Species | Human |
| Gene Type | protein-coding |
| Description | BPI fold containing family A, member 1 |
| Other Description | BPI fold-containing family A member 1|ligand-binding protein RYA3|lung-specific protein X|nasopharyngeal carcinoma-related protein|palate lung and nasal epithelium clone protein|palate, lung and nasal epithelium associated|protein Plunc|secretory protein in upper respiratory tracts|short PLUNC1|tracheal epithelium enriched protein|tracheal epithelium-enriched protein|von Ebner protein Hl |
| Swissprots | Q9NZT0 A6XMV5 E1P5M9 A8K9R3 Q9NP55 |
| Accessions | AAG13653 AAO12200 EAW76327 EAW76328 EAW76329 Q9NP55 AB024937 BAA93633 AF158745 AAF82622 AF172993 AAF70860 AF417256 AAO12198 AF417257 AAO12199 AF439448 AAL87636 AK292778 BAF85467 AY359020 AAQ89379 BC012549 AAH12549 DQ846869 ABI63356 HQ447374 ADQ31860 XR_430298 NM_001243193 NP_001230122 NM_016583 NP_057667 NM_130852 NP_570913 |
| Function | Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Binds bacterial lipopolysaccharide (LPS). Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus. Plays a role in the airway inflammatory response after exposure to irritants. May attract macrophages and neutrophils. May be associated with tumor progression. {ECO:0000269|PubMed:11425234, ECO:0000269|PubMed:23132494, ECO:0000269|PubMed:23499554, ECO:0000269|PubMed:24043776, ECO:0000269|PubMed:24124190}. |
| Subcellular Location | Secreted {ECO:0000269|PubMed:11425234, ECO:0000269|PubMed:12920053, ECO:0000269|PubMed:15158712, ECO:0000269|PubMed:23499554, ECO:0000269|PubMed:24043776, ECO:0000269|PubMed:24124190}. Note=Apical side of airway epithelial cells. Detected in airway surface liquid, nasal mucus and sputum. |
| Tissue Specificity | Lung, upper airways and nasopharyngeal regions, including trachea and nasal epithelium. Specifically expressed in the secretory ducts and submucosal glands of tracheobronchial tissues. Highest expression in the trachea and progressive decrease from proximal (bronchial) to distal (bronchiolar) airways. Also expressed in lung cancers and some other types of cancer. {ECO:0000269|PubMed:11018263, ECO:0000269|PubMed:11251963, ECO:0000269|PubMed:12409287, ECO:0000269|PubMed:12920053}. |