BPIFA1

Gene Symbol	BPIFA1
Entrez Gene	51297
Alt Symbol	LUNX, NASG, PLUNC, SPLUNC1, SPURT, bA49G10.5
Species	Human
Gene Type	protein-coding
Description	BPI fold containing family A, member 1
Other Description	BPI fold-containing family A member 1|ligand-binding protein RYA3|lung-specific protein X|nasopharyngeal carcinoma-related protein|palate lung and nasal epithelium clone protein|palate, lung and nasal epithelium associated|protein Plunc|secretory protein in upper respiratory tracts|short PLUNC1|tracheal epithelium enriched protein|tracheal epithelium-enriched protein|von Ebner protein Hl
Swissprots	Q9NZT0 A6XMV5 E1P5M9 A8K9R3 Q9NP55
Accessions	AAG13653 AAO12200 EAW76327 EAW76328 EAW76329 Q9NP55 AB024937 BAA93633 AF158745 AAF82622 AF172993 AAF70860 AF417256 AAO12198 AF417257 AAO12199 AF439448 AAL87636 AK292778 BAF85467 AY359020 AAQ89379 BC012549 AAH12549 DQ846869 ABI63356 HQ447374 ADQ31860 XR_430298 NM_001243193 NP_001230122 NM_016583 NP_057667 NM_130852 NP_570913
Function	Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Binds bacterial lipopolysaccharide (LPS). Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus. Plays a role in the airway inflammatory response after exposure to irritants. May attract macrophages and neutrophils. May be associated with tumor progression. {ECO:0000269|PubMed:11425234, ECO:0000269|PubMed:23132494, ECO:0000269|PubMed:23499554, ECO:0000269|PubMed:24043776, ECO:0000269|PubMed:24124190}.
Subcellular Location	Secreted {ECO:0000269|PubMed:11425234, ECO:0000269|PubMed:12920053, ECO:0000269|PubMed:15158712, ECO:0000269|PubMed:23499554, ECO:0000269|PubMed:24043776, ECO:0000269|PubMed:24124190}. Note=Apical side of airway epithelial cells. Detected in airway surface liquid, nasal mucus and sputum.
Tissue Specificity	Lung, upper airways and nasopharyngeal regions, including trachea and nasal epithelium. Specifically expressed in the secretory ducts and submucosal glands of tracheobronchial tissues. Highest expression in the trachea and progressive decrease from proximal (bronchial) to distal (bronchiolar) airways. Also expressed in lung cancers and some other types of cancer. {ECO:0000269|PubMed:11018263, ECO:0000269|PubMed:11251963, ECO:0000269|PubMed:12409287, ECO:0000269|PubMed:12920053}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Plunc full length protein - ab139617 from Abcam Category Protein Source E. coli Species Human

BPIFA1 / SPLUNC1 Antibody Blocking Peptide - LS-E27875 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BPIFA1 / SPLUNC1 Antibody Blocking Peptide - LS-E27874 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BPIFA1 / SPLUNC1 Antibody Blocking Peptide - LS-E15640 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human PLUNC Protein - H00051297-P01 from Novus Biologicals Category Protein Prices $529.00 Sizes 25 µg Source Wheat Germ Species Human

Recombinant Human PLUNC Protein - NBP2-22716 from Novus Biologicals Category Protein Prices $329.00 Sizes 100 µg Source E.coli Species Human

BPIFA1 protein (His tag) - 30R-2972 from Fitzgerald Category Protein Prices $270.00 Sizes 100 µg Source E.coli

PLUNC Blocking Peptide - 33R-3412 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PLUNC Blocking Peptide - abx161196 from Abbexa Category Peptide Species Human, Rat

Plunc Peptide - AC21-2880-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Plunc Peptide - AC21-2881-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

PLUNC (20-256, His-tag) - AR50732PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

PLUNC (20-256, His-tag) - AR50732PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

PLUNC - H00051297-P01-02 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Source in vitro transl. Species Human

PLUNC - H00051297-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PLUNC - H00051297-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

BPIFA1, 20-256aa, Human, His tag, E.coli - 01-P1908 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

PLUNC fusion protein - ag0629 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

PLUNC fusion protein - ag17724 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Human BPIFA1 Recombinant Protein - GWB-PPAT70 from Genway Biotech Category Protein Prices $300.00, $900.00 Sizes 100 μg, 500 μg Source E.coli Species Human

Recombinant Human BPIFA1, GST-tagged - BPIFA1-1801H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human BPIFA1 - BPIFA1-842H from Creative Biomart Category Protein Source Mammalian Cells Species Human

Recombinant Palate/Lung And Nasal Epithelium Associated Protein (PLUNC) - RPH364Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Palate/Lung And Nasal Epithelium Associated Protein (PLUNC) - RPH364Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Palate/Lung And Nasal Epithelium Associated Protein (PLUNC) - RPH364Mu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

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