BPIFA1

Gene Symbol BPIFA1
Entrez Gene 51297
Alt Symbol LUNX, NASG, PLUNC, SPLUNC1, SPURT, bA49G10.5
Species Human
Gene Type protein-coding
Description BPI fold containing family A, member 1
Other Description BPI fold-containing family A member 1|ligand-binding protein RYA3|lung-specific protein X|nasopharyngeal carcinoma-related protein|palate lung and nasal epithelium clone protein|palate, lung and nasal epithelium associated|protein Plunc|secretory protein in upper respiratory tracts|short PLUNC1|tracheal epithelium enriched protein|tracheal epithelium-enriched protein|von Ebner protein Hl
Swissprots Q9NZT0 A6XMV5 E1P5M9 A8K9R3 Q9NP55
Accessions AAG13653 AAO12200 EAW76327 EAW76328 EAW76329 Q9NP55 AB024937 BAA93633 AF158745 AAF82622 AF172993 AAF70860 AF417256 AAO12198 AF417257 AAO12199 AF439448 AAL87636 AK292778 BAF85467 AY359020 AAQ89379 BC012549 AAH12549 DQ846869 ABI63356 HQ447374 ADQ31860 XR_430298 NM_001243193 NP_001230122 NM_016583 NP_057667 NM_130852 NP_570913
Function Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Binds bacterial lipopolysaccharide (LPS). Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus. Plays a role in the airway inflammatory response after exposure to irritants. May attract macrophages and neutrophils. May be associated with tumor progression. {ECO:0000269|PubMed:11425234, ECO:0000269|PubMed:23132494, ECO:0000269|PubMed:23499554, ECO:0000269|PubMed:24043776, ECO:0000269|PubMed:24124190}.
Subcellular Location Secreted {ECO:0000269|PubMed:11425234, ECO:0000269|PubMed:12920053, ECO:0000269|PubMed:15158712, ECO:0000269|PubMed:23499554, ECO:0000269|PubMed:24043776, ECO:0000269|PubMed:24124190}. Note=Apical side of airway epithelial cells. Detected in airway surface liquid, nasal mucus and sputum.
Tissue Specificity Lung, upper airways and nasopharyngeal regions, including trachea and nasal epithelium. Specifically expressed in the secretory ducts and submucosal glands of tracheobronchial tissues. Highest expression in the trachea and progressive decrease from proximal (bronchial) to distal (bronchiolar) airways. Also expressed in lung cancers and some other types of cancer. {ECO:0000269|PubMed:11018263, ECO:0000269|PubMed:11251963, ECO:0000269|PubMed:12409287, ECO:0000269|PubMed:12920053}.

PLUNC (A-11) - sc-271457 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PLUNC (A-11): sc-271457. Western blot analysis of full length human recombinant PLUNC.

PLUNC (H-40) - sc-134733 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

PLUNC (T-18) - sc-49249 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

PLUNC (Q-16) - sc-49248 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

PLUNC (J-22) - sc-133917 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Rabbit
Clonality Polyclonal
PLUNC (J-22): sc-133917. Western blot analysis of PLUNC expression in Jurkat whole cell lysate.

Anti-Plunc antibody - ab175456 from Abcam

Prices $370.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
All lanes : Anti-Plunc antibody (ab175456) at 2 µg/mlLane 1 : Secretions from Human primary airway cells in cultureLane 2 : Secretions from Human primary airway cells in cultureLane 3 : Secretions from Human bronchoalveolar lavage fluidLane 4 : Secretions from Human bronchoalveolar lavage fluid

Anti-Plunc antibody [EPR8381] - ab131163 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR8381
All lanes : Anti-Plunc antibody [EPR8381] (ab131163) at 1/1000 dilutionLane 1 : A549 cell lysateLane 2 : PC3 cell lysateLane 3 : Human lung squamous cell cancer lysateLane 4 : Human fetal lung lysateLane 5 : Jurkat cell lysateLane 6 : 293T cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit IgG at 1/2000 dilution

Anti-Plunc antibody - C-terminal - ab174758 from Abcam

Prices $370.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
All lanes : Anti-Plunc antibody - C-terminal (ab174758) at 2 µg/mlLane 1 : Secretions from Human primary airway cells in cultureLane 2 : Secretions from Human primary airway cells in cultureLane 3 : Human Bronchoalveolar Lavage fluidLane 4 : Human Bronchoalveolar Lavage fluiddeveloped using the ECL technique

Anti-BPIFA1 / SPLUNC1 Antibody (aa167-180) - LS-C186451 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-BPIFA1 / SPLUNC1 Antibody (Internal, clone EPR8381) - LS-C154539 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR8381
Western blot analysis on (A) A549, (B) PC-3, (C) human lung squamous cell cancer, (D) fetal lung, (E) Jurkat, and (F) 293T cell lysates using anti-PLUNC antibody.

Anti-BPIFA1 / SPLUNC1 Antibody (aa228-241) - LS-C186450 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
BPIFA1 antibody (2 ug/ml) staining of secretions from Human primary airway cells in culture (lanes 1 and 2), and in Human Bronchoalveolar Lavage fluid (lanes 3 and 4) . Data obtained from Dr. C Bingle, AURM, University of Sheffield, UK. Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-BPIFA1 / SPLUNC1 Antibody (aa101-150) IHC-plus™ - LS-B3549 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-PLUNC antibody IHC of human lung, respiratory epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3549 concentration 5 ug/ml.

PLUNC Antibody [Unconjugated] - AF1897 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Goat
Clonality Polyclonal

PLUNC Antibody (251512) - MAB1897 from Novus Biologicals

Prices $99.00, $249.00
Sizes 25 µg, 100 µg
Host Mouse
Clonality Monoclonal
Clone 251512

PLUNC Antibody - NBP1-58979 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: PLUNC Antibody [NBP1-58979] - Sample Tissue: Human 293T Antibody Dilution: 1.0 ug/ml

PLUNC Antibody - NBP2-26120 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Western Blot: PLUNC Antibody [NBP2-26120] - Staining of secretions from Human primary airway cells in culture (lanes 1 and 2), and in Human Bronchoalveolar Lavage fluid (lanes 3 and 4). Data obtained from Dr. C Bingle, AURM, University of Sheffield, UK. Primary incubation was 1 hour. Detected by chemiluminescence.

PLUNC Antibody (3C1) - H00051297-M05 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3C1

PLUNC Antibody [Biotin] - BAF1897 from Novus Biologicals

Prices $390.00
Sizes 50 µg
Host Goat
Clonality Polyclonal

Anti-PLUNC antibody produced in rabbit - AV42475 from Sigma-Aldrich

Prices $347.50, $347.50
Sizes 50 µg, 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-PLUNC: <B>Cat. No. AV42475</B>: Immunohistochemistry of PLUNC in Human Lung, respiRatory epethelium tissue with PLUNC antibody at 5.0 μg/mL.

Monoclonal Anti-PLUNC antibody produced in mouse - SAB1401687 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3C1
<B>Immunoblotting</B><BR/>Monoclonal Anti-PLUNC, antibody produced in mouse, clone 3C1, purified immunoglobulin: <B>Cat. No. SAB1401687</B>: Antibody concentration: 1.0 μg/mL. Specific band of ~54.27 kDa using immunogen protein lysate.

PLUNC antibody - middle region (ARP42475_P050) - ARP42475_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

BPIFA1--PLUNC-Antibody-internal-region - AF3753a from Abgent, a WuXi AppTec company

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
AF3753a (2 µg/ml) staining of secretions from Human primary airway cells in culture (lanes 1 and 2), and in Human Bronchoalveolar Lavage fluid (lanes 3 and 4) . Data obtained from Dr. C Bingle, AURM, University of Sheffield, UK. Primary incubation was 1 hour. Detected by chemiluminescence.

BPIFA1--PLUNC-Antibody-C-Term - AF3752a from Abgent, a WuXi AppTec company

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
AF3752a (2 µg/ml) staining of secretions from Human primary airway cells in culture (lanes 1 and 2), and in Human Bronchoalveolar Lavage fluid (lanes 3 and 4) . Data obtained from Dr. C Bingle, AURM, University of Sheffield, UK. Primary incubation was 1 hour. Detected by chemiluminescence.

Human PLUNC Antibody - AF1897 from R&D Systems

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Goat

Human PLUNC Affinity Purified Polyclonal Ab, Goat IgG - AF1897-SP from R&D Systems

Host Goat
Clonality Polyclonal
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