| Gene Symbol |
ARL2
|
| Entrez Gene |
402
|
| Alt Symbol |
ARFL2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ADP-ribosylation factor-like 2
|
| Other Description |
ADP-ribosylation factor-like protein 2
|
| Swissprots |
G3V184 P36404 Q9BUK8
|
| Accessions |
EAW74332 EAW74333 P36404 AF493888 AAM12602 AI076058 AI631767 AK223502 BAD97222 AK294580 BAG57771 BC002530 AAH02530 BG706294 BT006674 AAP35320 CN338497 EU832671 ACE87762 EU832750 ACE87082 L13687 AAC37606 NM_001199745 NP_001186674 NM_001667 NP_001658
|
| Function |
Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the effect of TBCD on epithelial cell detachment and tight and adherens junctions disassembly. Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. Component of a regulated secretory pathway involved in Ca(2+)-dependent release of acetylcholine. Required for normal progress through the cell cycle. {ECO:0000269|PubMed:10831612, ECO:0000269|PubMed:16525022, ECO:0000269|PubMed:18234692, ECO:00002
|
| Subcellular Location |
Mitochondrion intermembrane space. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Cytoplasm. Note=The complex formed with ARL2BP, ARL2 and SLC25A6 is expressed in mitochondria. The complex formed with ARL2BP, ARL2 and SLC25A4 is expressed in mitochondria (By similarity). Not detected in the Golgi, nucleus and on the mitotic spindle. Centrosome-associated throughout the cell cycle. Not detected to interphase microtubules. {ECO:0000250}.
|