ACTL6A

Gene Symbol	ACTL6A
Entrez Gene	86
Alt Symbol	ACTL6, ARPN-BETA, Arp4, BAF53A, INO80K
Species	Human
Gene Type	protein-coding
Description	actin-like 6A
Other Description	53 kDa BRG1-associated factor A|BAF complex 53 kDa subunit|BAF53|BRG1-associated factor 53A|INO80 complex subunit K|actin-like protein 6A|actin-related protein 4|actin-related protein Baf53a|arpNbeta|hArpN beta
Swissprots	O96019 B3KMN1 Q8TAE5 Q9BVS8 Q9H0W6 D3DNR9
Accessions	EAW78397 EAW78398 EAW78399 EAW78400 EAW78401 O96019 AA256726 AB015907 BAA74577 AB060168 BAB87844 AB061315 BAB87848 AF041474 AAC94991 AK021756 BAG51043 AK098691 AK223212 BAD96932 AL136608 CAB66543 BC000949 AAH00949 BC001391 AAH01391 BC035463 BC036371 AAH36371 CR533529 CAG38560 DB041143 EU832285 ACE87542 EU832370 ACE86855 HQ448270 ADQ32750 NM_004301 NP_004292 NM_177989 NP_817126 NM_178042 NP_829888
Function	Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for maximal ATPase activity of SMARCA4/BRG1/BAF190A and for association of the SMARCA4/BRG1/BAF190A containing remodeling complex BAF with chromatin/nuclear matrix. Belongs to the neural progenitors- specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post- mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF
Subcellular Location	Nucleus {ECO:0000269|PubMed:18026119}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ACTL6A - MBS1270708 from MyBioSource Species Human Accession BC001391

ACTL6A - MBS1272792 from MyBioSource Species Human Accession BC036371

Human ACTL6A ORF clone(NM_004301.3) - CDCL182555 from Creative Biomart Species Human Accession NM_004301.3

Human ACTL6A ORF Clone(NM_178042.2) - CDCR323086 from Creative Biomart Species Human Accession NM_178042.2

Human ACTL6A ORF Clone(NM_178042.2) - CDCR323087 from Creative Biomart Species Human Accession NM_178042.2

Human ACTL6A ORF Clone(NM_004301.3) - CDCL153034 from Creative Biomart Species Human Accession NM_004301.3

Human ACTL6A ORF Clone(NM_004301.3) - CDCL153035 from Creative Biomart Species Human Accession NM_004301.3

Human Actin-like protein 6A/BAF53a Gene ORF cDNA clone in cloning vector - HG10963-M from Sino Biological Species Human

Human Actin-like protein 6A/BAF53a Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10963-M-F from Sino Biological Species Human

Human Actin-like protein 6A/BAF53a Gene ORF cDNA clone expression plasmid, N-His tag - HG10963-NH from Sino Biological Species Human

Human Actin-like protein 6A/BAF53a Gene ORF cDNA clone expression plasmid, N-HA tag - HG10963-NY from Sino Biological Species Human

Human Actin-like protein 6A/BAF53a Gene ORF cDNA clone expression plasmid - HG10963-M-N from Sino Biological Species Human

Human Actin-like protein 6A/BAF53a Gene ORF cDNA clone expression plasmid, C-His tag - HG10963-CH from Sino Biological Species Human

Human Actin-like protein 6A/BAF53a Gene ORF cDNA clone expression plasmid - HG10963-UT from Sino Biological Species Human

Human Actin-like protein 6A/BAF53a Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG10963-ACG from Sino Biological Species Human

Human Actin-like protein 6A/BAF53a Gene ORF cDNA clone expression plasmid, N-Flag tag - HG10963-NF from Sino Biological Species Human

Human Actin-like protein 6A/BAF53a Gene ORF cDNA clone expression plasmid, N-Myc tag - HG10963-NM from Sino Biological Species Human

Human Actin-like protein 6A/BAF53a Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10963-CF from Sino Biological Species Human

Human Actin-like protein 6A/BAF53a Gene ORF cDNA clone expression plasmid, C-HA tag - HG10963-CY from Sino Biological Species Human

Human Actin-like protein 6A/BAF53a Gene ORF cDNA clone expression plasmid, C-Myc tag - HG10963-CM from Sino Biological Species Human

Human Actin-like protein 6A/BAF53a Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG10963-ANG from Sino Biological Species Human

ACTL6A - CL01058H01 from Elabscience Species Human Accession NM_004301.3

ACTL6A - CL01058H02 from Elabscience Species Human Accession NM_177989.2

ACTL6A - CL01058H03 from Elabscience Species Human Accession NM_178042.2

Human ACTL6A ORF clone(NM_004301.3) - CDCL182555 from Creative biogene Species Human

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