ACTL6A
| Gene Symbol | ACTL6A |
|---|---|
| Entrez Gene | 86 |
| Alt Symbol | ACTL6, ARPN-BETA, Arp4, BAF53A, INO80K |
| Species | Human |
| Gene Type | protein-coding |
| Description | actin-like 6A |
| Other Description | 53 kDa BRG1-associated factor A|BAF complex 53 kDa subunit|BAF53|BRG1-associated factor 53A|INO80 complex subunit K|actin-like protein 6A|actin-related protein 4|actin-related protein Baf53a|arpNbeta|hArpN beta |
| Swissprots | O96019 B3KMN1 Q8TAE5 Q9BVS8 Q9H0W6 D3DNR9 |
| Accessions | EAW78397 EAW78398 EAW78399 EAW78400 EAW78401 O96019 AA256726 AB015907 BAA74577 AB060168 BAB87844 AB061315 BAB87848 AF041474 AAC94991 AK021756 BAG51043 AK098691 AK223212 BAD96932 AL136608 CAB66543 BC000949 AAH00949 BC001391 AAH01391 BC035463 BC036371 AAH36371 CR533529 CAG38560 DB041143 EU832285 ACE87542 EU832370 ACE86855 HQ448270 ADQ32750 NM_004301 NP_004292 NM_177989 NP_817126 NM_178042 NP_829888 |
| Function | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for maximal ATPase activity of SMARCA4/BRG1/BAF190A and for association of the SMARCA4/BRG1/BAF190A containing remodeling complex BAF with chromatin/nuclear matrix. Belongs to the neural progenitors- specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post- mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:18026119}. |
BAF53 CRISPR/Cas9 KO Plasmid (h) - sc-403200 from Santa Cruz Biotechnology
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BAF53 HDR Plasmid (h) - sc-403200-HDR from Santa Cruz Biotechnology
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BAF53 Double Nickase Plasmid (h) - sc-403200-NIC from Santa Cruz Biotechnology
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BAF53 Double Nickase Plasmid (h2) - sc-403200-NIC-2 from Santa Cruz Biotechnology
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BAF53 CRISPR Activation Plasmid (h) - sc-403200-ACT from Santa Cruz Biotechnology
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BAF53 CRISPR Activation Plasmid (h2) - sc-403200-ACT-2 from Santa Cruz Biotechnology
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BAF53 Lentiviral Activation Particles (h) - sc-403200-LAC from Santa Cruz Biotechnology
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BAF53 Lentiviral Activation Particles (h2) - sc-403200-LAC-2 from Santa Cruz Biotechnology
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BAF53 siRNA (h) - sc-60239 from Santa Cruz Biotechnology
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BAF53 shRNA Plasmid (h) - sc-60239-SH from Santa Cruz Biotechnology
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BAF53 shRNA (h) Lentiviral Particles - sc-60239-V from Santa Cruz Biotechnology
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BAF53A RNAi - H00000086-R01 from Novus Biologicals
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MISSION® esiRNA - EHU132371 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2773 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2773 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02979 from Sigma-Aldrich
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ACTL6A siRNA (Human) - CRH0052 from Cohesion Biosciences
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BAF53A RNAi - H00000086-R03 from Novus Biologicals
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BAF53A RNAi - H00000086-R02 from Novus Biologicals
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ACTL6A - MBS8238657 from MyBioSource
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shRNA set against Human ACTL6A (NM_178042.2) - SHH230962 from Creative biogene
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shRNA set against Human ACTL6A(NM_177989.2) - SHG036353 from Creative biogene
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shRNA set against Human ACTL6A(NM_004301.3) - SHG036371 from Creative biogene
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BAF53 CRISPR/Cas9 KO Plasmid (h2) - sc-403200-KO-2 from Santa Cruz Biotechnology
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BAF53 HDR Plasmid (h2) - sc-403200-HDR-2 from Santa Cruz Biotechnology
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