| Gene Symbol |
WHSC1L1
|
| Entrez Gene |
54904
|
| Alt Symbol |
NSD3, pp14328
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Wolf-Hirschhorn syndrome candidate 1-like 1
|
| Other Description |
WHSC1-like 1 isoform 9 with methyltransferase activity to lysine|WHSC1-like protein 1|histone-lysine N-methyltransferase NSD3|nuclear SET domain-containing protein 3|protein whistle
|
| Swissprots |
Q9BYU8 D3DSX1 Q9BZ95 Q9NXA6 Q1RMD3 Q9H9W9 B7ZL11 Q6ZSA5 Q9BYU9 Q3B796 Q9H2M8
|
| Accessions |
EAW63319 EAW63320 EAW63321 EAW63322 Q9BZ95 AF255649 AAG44637 AF318339 AAL55846 AF332468 AAK00354 AF332469 AAK00355 AJ295990 CAC28350 AJ295991 CAC28351 AJ295992 CAC28352 AK000360 BAA91110 AK022560 BAB14099 AK023534 AK025702 AK092166 AK127594 AL832895 BC000030 BC007787 BC012059 AAH12059 BC062631 AAH62631 BC073858 BC101717 AAI01718 BC107734 AAI07735 BC113469 AAI13470 BC115006 AAI15007 BC115007 BC143510 AAI43511 JF432144 ADZ15361 XM_005273547 XP_005273604 XM_005273548 XP_005273605 XM_011544561 XP_011542863 XM_011544562 XP_011542864 XM_011544563 XP_011542865 NM_017778 NP_060248 NM_023034 NP_075447
|
| Function |
Histone methyltransferase. Preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression. {ECO:0000269|PubMed:16682010}.
|
| Subcellular Location |
Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
|
| Tissue Specificity |
Highly expressed in brain, heart and skeletal muscle. Expressed at lower level in liver and lung. {ECO:0000269|PubMed:11374904}.
|
| Top Pathways |
Lysine degradation
|