DICER1

Gene Symbol	DICER1
Entrez Gene	23405
Alt Symbol	DCR1, Dicer, Dicer1e, HERNA, K12H4.8-LIKE, MNG1, RMSE2
Species	Human
Gene Type	protein-coding
Description	dicer 1, ribonuclease type III
Other Description	Dicer1, Dcr-1 homolog|dicer 1, double-stranded RNA-specific endoribonuclease|endoribonuclease Dicer|helicase MOI|helicase with RNAse motif
Swissprots	E0AD28 Q9UQ02 B3KRG4 A7E2D3 Q9UPY3 O95943
Accessions	CBM42912 CBV35645 EAW81595 EAW81596 Q9UPY3 AB023145 BAA76772 AB028449 BAA78691 AF007142 AJ132261 CAB38857 AK001041 AK001827 AK002007 BAG51002 AK091094 AK091513 BAG52376 AL122105 CAB59269 AL832389 AW297296 AY845867 AAW31883 AY845868 AAW31884 AY929254 AAX18334 AY929255 AAX18335 AY929256 AAX18336 BC046934 BC068591 BC150287 AAI50288 BI913232 BM152875 BP199059 BQ937506 HM595745 ADK25182 KJ175111 AIK25433 XM_011536599 XP_011534901 XM_011536600 XP_011534902 XM_011536601 XP_011534903 XM_011536602 XP_011534904 XM_011536603 XP_011534905 XM_011536604 XP_011534906 XM_011536605 XP_011534907 NM_001195573 NP_001182502 NM_001271282 NP_001258211 NM_001291628 NP_001278557 NM_030621 NP_085124 NM_177438 NP_803187
Function	Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA- induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes. {ECO:0000269|PubMed:15242644, ECO:0000269|PubMed:15973356, ECO:0000269|PubMed:16142218, ECO:0000269|PubMed:16271387, ECO:0000269|PubMe
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:16424907}.
Top Pathways	MicroRNAs in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human DICER1 / Dicer ELISA Kit (Sandwich ELISA) - LS-F7611 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.312 ng/ml Range 0.312-20 ng/ml

Human DICER1 ELISA Kit - abx151315 from Abbexa Category ELISA Kit Sensitivity 0.115 ng/ml Range 0.313 ng/ml - 20 ng/ml

Dicer 1, Ribonuclease Type III (DICER1), Human, ELISA Kit - SEK448Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.115ng/mL Range 0.312-20ng/mL

Endoribonuclease Dicer, DICER1, Human, ELISA Kit - E0156h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.312-20 ng/mL

Dicer 1, Ribonuclease Type III, ELISA Kit - MBS098835 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Dicer 1, Ribonuclease Type III, ELISA Kit - MBS095609 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Dicer 1, Ribonuclease Type III, ELISA Kit - MBS096409 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Dicer 1, Ribonuclease Type III, ELISA Kit - MBS105182 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Dicer 1, Ribonuclease Type III, ELISA Kit - MBS062436 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Dicer 1, Ribonuclease Type III, ELISA Kit - MBS075240 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Dicer 1, Ribonuclease Type III, ELISA Kit - MBS052712 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1ng/ml. Range 0.625ng/ml-20ng/ml.

Dicer 1, Ribonuclease Type III (DICER1), ELISA Kit - MBS2021899 from MyBioSource Category ELISA Kit Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.119ng/mL. Range 0.313-20ng/mL

Endoribonuclease Dicer (DICER1) - MBS9318375 from MyBioSource Category ELISA Kit Prices $435.00, $600.00 Sizes 48 strip wells, 96 strip wells

ELISA Kit for Dicer 1, Ribonuclease Type III (DICER1) - SEK448Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.122ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA’s were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

ELISA Kit for Dicer 1, Ribonuclease Type III (DICER1) - SEK448Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.122ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA's were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

Chicken DICER1 / Dicer ELISA Kit (Custom ELISA) - LS-F13870 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range 0.312-20 ng/ml

Bovine DICER1 / Dicer ELISA Kit (Custom ELISA) - LS-F13871 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range 0.312-20 ng/ml

Mouse DICER1 / Dicer ELISA Kit (Sandwich ELISA) - LS-F13873 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.78 ng/ml Range 0.312-20 ng/ml

Human DICER1 / Dicer ELISA Kit (Custom ELISA) - LS-F13872 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.312-20 ng/ml

Human Dicer 1, Ribonuclease Type III (DICER1) ELISA Kit - EKU03728 from Biomatik Category ELISA Kit Prices $735.00, $3,234.00, $5,880.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 0.112 ng/mL Range 0.312-20 ng/mL

Human Endoribonuclease Dicer ELISA Kit - abx253689 from Abbexa Category ELISA Kit Range 0.312 ng/ml - 20 ng/ml

Dicer 1, Ribonuclease Type III (DICER1), Human, ELISA Kit - DL-DICER1-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 0.312-20 ng/mL

Human DICER1 ELISA Kit - abx572595 from Abbexa Category ELISA Kit Sensitivity 0.115 ng/ml Range 0.313 ng/ml - 20 ng/ml

Human Human Endoribonuclease Dicer ELISA Kit - EKE52981 from Biomatik Category ELISA Kit Prices $685.00, $2,913.00, $5,483.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 0.11 ng/mL Range 0.312-20 ng/mL

DICER1 - EKH1462 from Nordic BioSite Sensitivity 0.188ng/ml Range 0.312-20ng/ml

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