| Gene Symbol |
DICER1
|
| Entrez Gene |
23405
|
| Alt Symbol |
DCR1, Dicer, Dicer1e, HERNA, K12H4.8-LIKE, MNG1, RMSE2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
dicer 1, ribonuclease type III
|
| Other Description |
Dicer1, Dcr-1 homolog|dicer 1, double-stranded RNA-specific endoribonuclease|endoribonuclease Dicer|helicase MOI|helicase with RNAse motif
|
| Swissprots |
E0AD28 Q9UQ02 B3KRG4 A7E2D3 Q9UPY3 O95943
|
| Accessions |
CBM42912 CBV35645 EAW81595 EAW81596 Q9UPY3 AB023145 BAA76772 AB028449 BAA78691 AF007142 AJ132261 CAB38857 AK001041 AK001827 AK002007 BAG51002 AK091094 AK091513 BAG52376 AL122105 CAB59269 AL832389 AW297296 AY845867 AAW31883 AY845868 AAW31884 AY929254 AAX18334 AY929255 AAX18335 AY929256 AAX18336 BC046934 BC068591 BC150287 AAI50288 BI913232 BM152875 BP199059 BQ937506 HM595745 ADK25182 KJ175111 AIK25433 XM_011536599 XP_011534901 XM_011536600 XP_011534902 XM_011536601 XP_011534903 XM_011536602 XP_011534904 XM_011536603 XP_011534905 XM_011536604 XP_011534906 XM_011536605 XP_011534907 NM_001195573 NP_001182502 NM_001271282 NP_001258211 NM_001291628 NP_001278557 NM_030621 NP_085124 NM_177438 NP_803187
|
| Function |
Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA- induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes. {ECO:0000269|PubMed:15242644, ECO:0000269|PubMed:15973356, ECO:0000269|PubMed:16142218, ECO:0000269|PubMed:16271387, ECO:0000269|PubMe
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:16424907}.
|
| Top Pathways |
MicroRNAs in cancer
|