| Gene Symbol |
SERPINB5
|
| Entrez Gene |
5268
|
| Alt Symbol |
PI5, maspin
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
serpin peptidase inhibitor, clade B (ovalbumin), member 5
|
| Other Description |
PI-5|peptidase inhibitor 5|protease inhibitor 5 (maspin)|serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 5|serpin B5
|
| Swissprots |
Q6N0B4 P36952 Q8WW89 B2R6Y4
|
| Accessions |
EAW63145 EAW63146 EAW63147 EAW63148 P36952 AK301667 BAG63141 AK312765 BAG35631 AL602439 BC020713 AAH20713 BM955647 BX640597 CAE45703 CV575332 U04313 AAA18957 XM_006722483 XP_006722546 NM_002639 NP_002630
|
| Function |
Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
|
| Subcellular Location |
Secreted, extracellular space.
|
| Tissue Specificity |
Normal mammary epithelial cells.
|
| Top Pathways |
p53 signaling pathway, MicroRNAs in cancer
|