Gene Symbol | SERPINB5 |
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Entrez Gene | 5268 |
Alt Symbol | PI5, maspin |
Species | Human |
Gene Type | protein-coding |
Description | serpin peptidase inhibitor, clade B (ovalbumin), member 5 |
Other Description | PI-5|peptidase inhibitor 5|protease inhibitor 5 (maspin)|serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 5|serpin B5 |
Swissprots | Q6N0B4 P36952 Q8WW89 B2R6Y4 |
Accessions | EAW63145 EAW63146 EAW63147 EAW63148 P36952 AK301667 BAG63141 AK312765 BAG35631 AL602439 BC020713 AAH20713 BM955647 BX640597 CAE45703 CV575332 U04313 AAA18957 XM_006722483 XP_006722546 NM_002639 NP_002630 |
Function | Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. |
Subcellular Location | Secreted, extracellular space. |
Tissue Specificity | Normal mammary epithelial cells. |
Top Pathways | p53 signaling pathway, MicroRNAs in cancer |
Maspin CRISPR/Cas9 KO Plasmid (h) - sc-416693 from Santa Cruz Biotechnology
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Maspin HDR Plasmid (h) - sc-416693-HDR from Santa Cruz Biotechnology
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Maspin Double Nickase Plasmid (h) - sc-416693-NIC from Santa Cruz Biotechnology
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Maspin Double Nickase Plasmid (h2) - sc-416693-NIC-2 from Santa Cruz Biotechnology
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Maspin CRISPR Activation Plasmid (h) - sc-416693-ACT from Santa Cruz Biotechnology
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Maspin CRISPR Activation Plasmid (h2) - sc-416693-ACT-2 from Santa Cruz Biotechnology
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Maspin Lentiviral Activation Particles (h) - sc-416693-LAC from Santa Cruz Biotechnology
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Maspin Lentiviral Activation Particles (h2) - sc-416693-LAC-2 from Santa Cruz Biotechnology
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Maspin siRNA (h) - sc-35859 from Santa Cruz Biotechnology
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Maspin shRNA Plasmid (h) - sc-35859-SH from Santa Cruz Biotechnology
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Maspin shRNA (h) Lentiviral Particles - sc-35859-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU034991 from Sigma-Aldrich
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MISSION® esiRNA - EHU126361 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19145 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19145 from Sigma-Aldrich
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SERPINB5 siRNA (Human) - CRH3517 from Cohesion Biosciences
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SERPINB5 - MBS8231891 from MyBioSource
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SERPINB5 shRNA Plasmid (Human) - CHH3517 from Cohesion Biosciences
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