| Gene Symbol |
TBX6
|
| Entrez Gene |
6911
|
| Alt Symbol |
SCDO5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
T-box 6
|
| Other Description |
T-box protein 6|T-box transcription factor TBX6
|
| Swissprots |
O95947 Q9HA44 Q8TAS4
|
| Accessions |
CAB37938 EAW79926 EAW79927 O95947 AJ007989 CAA07812 AK022330 BAB14014 BC026031 AAH26031 EU446659 ABZ92188 KJ534981 AHW56621 KJ535035 AHW56674 XM_005255523 XP_005255580 XM_011545926 XP_011544228 XR_950840 NM_004608 NP_004599 NM_080758
|
| Function |
T-box transcription factor that plays an essential role in the determination of the fate of axial stem cells: neural vs mesodermal. Acts in part by down-regulating, a specific enhancer (N1) of SOX2, to inhibit neural development. Seems to play also an essential role in left/right axis determination and acts through effects on Notch signaling around the node as well as through an effect on the morphology and motility of the nodal cilia (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00201}.
|
| Tissue Specificity |
Expressed in fetal tail bud, posterior spinal tissue, intervertebral disk and testis. Also expressed in adult testis, kidney, lung, muscle and thymus.
|