TBX6

Gene Symbol TBX6
Entrez Gene 6911
Alt Symbol SCDO5
Species Human
Gene Type protein-coding
Description T-box 6
Other Description T-box protein 6|T-box transcription factor TBX6
Swissprots O95947 Q9HA44 Q8TAS4
Accessions CAB37938 EAW79926 EAW79927 O95947 AJ007989 CAA07812 AK022330 BAB14014 BC026031 AAH26031 EU446659 ABZ92188 KJ534981 AHW56621 KJ535035 AHW56674 XM_005255523 XP_005255580 XM_011545926 XP_011544228 XR_950840 NM_004608 NP_004599 NM_080758
Function T-box transcription factor that plays an essential role in the determination of the fate of axial stem cells: neural vs mesodermal. Acts in part by down-regulating, a specific enhancer (N1) of SOX2, to inhibit neural development. Seems to play also an essential role in left/right axis determination and acts through effects on Notch signaling around the node as well as through an effect on the morphology and motility of the nodal cilia (By similarity). {ECO:0000250}.
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00201}.
Tissue Specificity Expressed in fetal tail bud, posterior spinal tissue, intervertebral disk and testis. Also expressed in adult testis, kidney, lung, muscle and thymus.

TBX6 (U-23) - sc-134063 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Rabbit
Clonality Polyclonal
TBX6 (U-23): sc-134063. Western blot analysis of TBX6 expression in Hep G2 whole cell lysate.

Anti-Tbx6 antibody - ab38883 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Tbx6 antibody (ab38883) at 1 µg/mlLane 1 : Testis (Mouse) Tissue LysateLane 2 : Lung (Mouse) Tissue LysateLane 3 : Testis (Human) Tissue Lysate - adult normal tissue (ab30257)Lane 4 : Lung (Human) Tissue LysateLysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutionPerformed under reducing conditions.

Anti-Tbx6 antibody - ab58255 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Overlay histogram showing HEK293 cells stained with ab58255 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab58255, 1μg/1x106 cells) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-mouse IgG (H&L) (ab150113) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was mouse IgG2a [ICIGG2A] (ab91361, 1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.

Anti-Tbx6 antibody - ab30946 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Tbx6 antibody (ab30946) at 1.25 µg/ml + Jurkat cell lysate at 10 µgSecondaryHRP conjugated anti rabbit IgG at 1/50000 dilution

Anti-Tbx6 antibody - C-terminal - ab170482 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Flow cytometric analysis of K562 cells (right/green histogram) compared to a negative control cell (left/blue histogram) labeling Tbx6 with ab170482 at 1/10 dilution. FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

Anti-TBX6 Antibody - LS-C76243 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-TBX6 Antibody (aa271-301, APC) - LS-C241631 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TBX6 Antibody (aa271-301, AP) - LS-C241632 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TBX6 Antibody (aa271-301, Biotin) - LS-C241633 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TBX6 Antibody (aa268-317) - LS-C29938 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Jurkat Cell Lysate

Anti-TBX6 Antibody (aa271-301, FITC) - LS-C241634 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TBX6 Antibody (aa62-111) - LS-C31631 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Placenta Lysate

Anti-TBX6 Antibody (aa271-301, PE) - LS-C241638 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TBX6 Antibody (aa271-301) - LS-C325623 from LifeSpan Bioscience

Prices $435.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TBX6 Antibody (aa62-111) - LS-C29983 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
TBX6 antibody LS-C29983 was used in IHC to stain formalin-fixed, paraffin-embedded human muscle.

Anti-TBX6 Antibody (aa360-409) - LS-C112151 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
TBX6 antibody LS-C112151 Western blot of Fetal Brain lysate.

Anti-TBX6 Antibody (aa264-293) - LS-C161756 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Fluorescent confocal image of HeLa cell stained with TBX6 Antibody. HeLa cells were fixed with 4% PFA (20 min), permeabilized with Triton X-100 (0.1%, 10 min), then incubated with TBX6 primary antibody (1:25, 1 h at 37°C). For secondary antibody, Alexa Fluor 488 conjugated donkey anti-rabbit antibody (green) was used (1:400, 50 min at 37°C). Cytoplasmic actin was counterstained with Alexa Fluor 555 (red) conjugated Phalloidin (7units/ml, 1 h at 37°C). Nuclei were counterstained with DAPI (blue) (10 ug/ml, 10 min). TBX6 immunoreactivity is localized to nucleus significantly.

Anti-TBX6 Antibody (aa143-172) - LS-C161754 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
TBX6 Antibody western blot of K562 cell line lysates (35 ug/lane). The TBX6 antibody detected the TBX6 protein (arrow).

Anti-TBX6 Antibody (clone 2D11) - LS-C198308 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2D11
Immunofluorescence of monoclonal antibody to TBX6 on HeLa cell . [antibody concentration 10 ug/ml]

Anti-TBX6 Antibody (aa143-172) - LS-C161755 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
TBX6 Antibody (Center W158) western blot of HeLa cell line and mouse liver tissue lysates (35 ug/lane). The TBX6 antibody detected the TBX6 protein (arrow).

Anti-TBX6 Antibody (aa361-377) IHC-plus™ - LS-B911 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-TBX6 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B911 concentration 10 ug/ml.

Anti-TBX6 Antibody (aa271-301, Azide-free, HRP) - LS-C247034 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

TBX6 Antibody [Unconjugated] - AF4744 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Goat
Clonality Polyclonal
Western blot shows lysates of HEK293 human embryonic kidney cell line, HT1080 human fibrosarcoma cell line, and HL‑60 human acute promyelocytic leukemia cell line. PVDF membrane was probed with 1 µg/mL of Human TBX6 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF4744) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF019). A specific band was detected for TBX6 at approximately 45 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 8.

TBX6 Antibody (1D11) - H00006911-M06 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1D11
Western Blot: TBX6 Antibody (1D11) [H00006911-M06] - Analysis of TBX6 expression in HeLa (Cat # L013V1).

TBX6 Antibody - NBP1-02529 from Novus Biologicals

Prices $329.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: Tbx6 Antibody [NBP1-02529] - Staining of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Search more