| Gene Symbol | DSP |
|---|---|
| Entrez Gene | 1832 |
| Alt Symbol | DCWHKTA, DP, DPI, DPII |
| Species | Human |
| Gene Type | protein-coding |
| Description | desmoplakin |
| Other Description | 250/210 kDa paraneoplastic pemphigus antigen|desmoplakin I|desmoplakin II |
| Swissprots | D7RX09 P15924 Q9UHN4 O75993 Q14189 B2RTT2 |
| Accessions | CAP07480 CAP07499 CAP11448 CAP11467 CAR97062 CAR97081 CAT82278 CAT82313 EAW55215 P15924 AB209992 BAE06074 AB621818 BAK64154 AF139065 AAF19785 AI304615 AK130229 BAC85309 AK296756 BAG59338 AK301676 BAG63149 AK304182 BAG65062 AL713599 AL713610 AW890985 BC140802 AAI40803 BC144587 CN282963 HM151899 ADI58529 J05211 AAA35766 M77830 AAA85135 XM_011514323 XP_011512625 NM_001008844 NP_001008844 NM_004415 NP_004406 |
| Function | Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin- plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes. |
| Subcellular Location | Cell junction, desmosome {ECO:0000269|PubMed:12802069}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12802069}. Note=Innermost portion of the desmosomal plaque. Colocalizes with epidermal KRT5-KRT14 and simple KRT8-KRT18 keratins and VIM intermediate filaments network. |
| Tissue Specificity | Isoform DPI is apparently an obligate constituent of all desmosomes. Isoform DPII resides predominantly in tissues and cells of stratified origin. |
| Top Pathways | Arrhythmogenic right ventricular cardiomyopathy (ARVC) |
desmoplakin I/II CRISPR/Cas9 KO Plasmid (h) - sc-400818 from Santa Cruz Biotechnology
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desmoplakin I/II HDR Plasmid (h) - sc-400818-HDR from Santa Cruz Biotechnology
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desmoplakin I/II Double Nickase Plasmid (h) - sc-400818-NIC from Santa Cruz Biotechnology
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desmoplakin I/II Double Nickase Plasmid (h2) - sc-400818-NIC-2 from Santa Cruz Biotechnology
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desmoplakin I/II CRISPR Activation Plasmid (h) - sc-400818-ACT from Santa Cruz Biotechnology
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desmoplakin I/II CRISPR Activation Plasmid (h2) - sc-400818-ACT-2 from Santa Cruz Biotechnology
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desmoplakin I/II Lentiviral Activation Particles (h) - sc-400818-LAC from Santa Cruz Biotechnology
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desmoplakin I/II Lentiviral Activation Particles (h2) - sc-400818-LAC-2 from Santa Cruz Biotechnology
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desmoplakin I/II siRNA (h) - sc-43724 from Santa Cruz Biotechnology
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desmoplakin I/II shRNA Plasmid (h) - sc-43724-SH from Santa Cruz Biotechnology
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desmoplakin I/II shRNA (h) Lentiviral Particles - sc-43724-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU007001 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7513 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7513 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06526 from Sigma-Aldrich
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DSP siRNA (Human) - CRH1281 from Cohesion Biosciences
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DSP - MBS8211349 from MyBioSource
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desmoplakin I/II CRISPR/Cas9 KO Plasmid (h2) - sc-400818-KO-2 from Santa Cruz Biotechnology
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desmoplakin I/II HDR Plasmid (h2) - sc-400818-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human DSP(NM_004415.2) - SHH016823 from Creative biogene
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shRNA set against Human DSP(NM_001008844.1) - SHH016825 from Creative biogene
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shRNA set against Human DSP(NM_004415.2) - SHH016831 from Creative biogene
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shRNA set against Human DSP(NM_001008844.1) - SHH016847 from Creative biogene
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Human DSP siRNA - orb261783 from Biorbyt
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DSP shRNA Plasmid (Human) - CHH1281 from Cohesion Biosciences
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