DSP

Gene Symbol DSP
Entrez Gene 1832
Alt Symbol DCWHKTA, DP, DPI, DPII
Species Human
Gene Type protein-coding
Description desmoplakin
Other Description 250/210 kDa paraneoplastic pemphigus antigen|desmoplakin I|desmoplakin II
Swissprots D7RX09 P15924 Q9UHN4 O75993 Q14189 B2RTT2
Accessions CAP07480 CAP07499 CAP11448 CAP11467 CAR97062 CAR97081 CAT82278 CAT82313 EAW55215 P15924 AB209992 BAE06074 AB621818 BAK64154 AF139065 AAF19785 AI304615 AK130229 BAC85309 AK296756 BAG59338 AK301676 BAG63149 AK304182 BAG65062 AL713599 AL713610 AW890985 BC140802 AAI40803 BC144587 CN282963 HM151899 ADI58529 J05211 AAA35766 M77830 AAA85135 XM_011514323 XP_011512625 NM_001008844 NP_001008844 NM_004415 NP_004406
Function Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin- plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes.
Subcellular Location Cell junction, desmosome {ECO:0000269|PubMed:12802069}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12802069}. Note=Innermost portion of the desmosomal plaque. Colocalizes with epidermal KRT5-KRT14 and simple KRT8-KRT18 keratins and VIM intermediate filaments network.
Tissue Specificity Isoform DPI is apparently an obligate constituent of all desmosomes. Isoform DPII resides predominantly in tissues and cells of stratified origin.
Top Pathways Arrhythmogenic right ventricular cardiomyopathy (ARVC)

Phospho-Desmoplakin (Ser165/166) Antibody - 5885 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from A-431 and Calu-3 cells, untreated or treated with calf intestinal phosphatase (CIP) and λ phosphatase, using Phospho-Desmoplakin (Ser165/166) Antibody.

desmoplakin I (H-14) - sc-18083 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

desmoplakin I/II (B-1) - sc-365981 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
desmoplakin I/II (B-1): sc-365981. Western blot analysis of desmoplakin I/II expression in CCD-1064Sk whole cell lysate.

desmoplakin I/II (A-1) - sc-390975 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
desmoplakin I/II (A-1): sc-390975. Western blot analysis of desmoplakin I/II expression in HeLa whole cell lysate.

desmoplakin I/II (C-20) - sc-18086 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
desmoplakin I/II (C-20): sc-18086. Western blot analysis of desmoplakin I/II expression in HeLa whole cell lysate.

desmoplakin I/II (G-2) - sc-373789 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
desmoplakin I/II (G-2): sc-373789. Western blot analysis of desmoplakin I/II expression in HeLa whole cell lysate.

desmoplakin I/II (G-20) - sc-18082 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
desmoplakin I/II (G-20): sc-18082. Western blot analysis of desmoplakin I/II expression in HeLa (A) and MIA PaCa-2 (B) whole cell lysates.

desmoplakin I/II (H-300) - sc-33555 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
desmoplakin I/II (H-300): sc-33555. Immunofluores-cence staining of methanol-fixed HeLa cells showing cytoplasmic localization.

Anti-Desmoplakin antibody - ab136677 from Abcam

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Immunohistochemical analysis of Paraffin-embedded Human heart tissue labelling Desmoplakin with ab136677 at 3.8 µg/ml, AP-staining.

Anti-Desmoplakin antibody - ab106342 from Abcam

Prices $370.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Desmoplakin antibody [EPR4383(2)] - ab109445 from Abcam

Prices $381.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4383(2)
All lanes : Anti-Desmoplakin antibody [EPR4383(2)] (ab109445) at 1/1000 dilutionLane 1 : A431 cell lysateLane 2 : HACAT cell lysateLane 3 : BXPC-3 cell lysateLysates/proteins at 10 µg per lane.

Anti-Desmoplakin I+II antibody - ab71690 from Abcam

Prices $387.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Desmoplakin I+II antibody (ab71690) at 1 µg/ml + Caco 2 (Human colonic carcinoma cell line) Whole Cell Lysate at 10 µgSecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution

Anti-Desmoplakin I+II antibody - ab118804 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Detection of Desmoplakin I+II in Immunoprecipitates of HeLa whole cell lysates (1 mg for IP, 20% of IP loaded) using ab118804 at 6 µg/mg lysate for IP (Lane 1). For WB detection an anti-Desmoplakin I+II antibody which recognizes a downstream epitope was used at 1 µg/ml. Lane 2 represents control IgG IP. Detection: Chemiluminescence with an exposure time of 10 seconds.

Anti-Desmoplakin I+II antibody - C-terminal - ab199903 from Abcam

Host Rabbit
Clonality Polyclonal
Anti-Desmoplakin I+II antibody - C-terminal (ab199903) at 1/1000 dilution + HeLa total cell extract

Anti-Desmoplakin I+II antibody - N-terminal - ab199931 from Abcam

Host Rabbit
Clonality Polyclonal
Anti-Desmoplakin I+II antibody - N-terminal (ab199931) at 1/1000 dilution + HeLa total cell extract

Anti-DSP / Desmoplakin Antibody - LS-C22821 from LifeSpan Bioscience

Prices $575.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-DSP / Desmoplakin Antibody - LS-C86059 from LifeSpan Bioscience

Prices $695.00
Sizes 50 µl
Host Guinea Pig
Clonality Polyclonal

Anti-DSP / Desmoplakin Antibody (clone DP 2.17) - LS-C85066 from LifeSpan Bioscience

Prices $560.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-DSP / Desmoplakin Antibody - LS-C22820 from LifeSpan Bioscience

Prices $665.00
Sizes 50 µl
Host Guinea Pig
Clonality Polyclonal

Anti-DSP / Desmoplakin Antibody (aa1546-1558) - LS-C139598 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-DSP / Desmoplakin Antibody (Internal) - LS-C145030 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-DSP / Desmoplakin Antibody (phospho-Ser2849) - LS-C209392 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-DSP / Desmoplakin Antibody (Internal) - LS-C153436 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DSP / Desmoplakin Antibody (aa1600-1650) - LS-C290040 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-DSP / Desmoplakin Antibody (aa1900-1950) - LS-C290043 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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