| Gene Symbol |
PLG
|
| Entrez Gene |
5340
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
plasminogen
|
| Other Description |
plasmin
|
| Swissprots |
Q6PA00 P00747 Q5TEH4 Q15146
|
| Accessions |
AAA60113 AAA60123 AAN85555 CBY88485 EAW47591 EAW47592 P00747 AK298338 BAG60586 AK308036 AK312966 BAG35805 BC060513 AAH60513 BU073846 CR749293 CAH18148 DR004070 K02922 AAA60124 M74220 AAA36451 X05199 CAA28831 NM_000301 NP_000292 NM_001168338 NP_001161810
|
| Function |
Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells. {ECO:0000269|PubMed:14699093}.
|
| Subcellular Location |
Secreted {ECO:0000269|PubMed:10077593, ECO:0000269|PubMed:14699093}. Note=Locates to the cell surface where it is proteolytically cleaved to produce the active plasmin. Interaction with HRG tethers it to the cell surface.
|
| Tissue Specificity |
Present in plasma and many other extracellular fluids. It is synthesized in the liver.
|
| Top Pathways |
Complement and coagulation cascades, Staphylococcus aureus infection, Influenza A, Neuroactive ligand-receptor interaction
|