PLG

Gene Symbol	PLG
Entrez Gene	5340
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	plasminogen
Other Description	plasmin
Swissprots	Q6PA00 P00747 Q5TEH4 Q15146
Accessions	AAA60113 AAA60123 AAN85555 CBY88485 EAW47591 EAW47592 P00747 AK298338 BAG60586 AK308036 AK312966 BAG35805 BC060513 AAH60513 BU073846 CR749293 CAH18148 DR004070 K02922 AAA60124 M74220 AAA36451 X05199 CAA28831 NM_000301 NP_000292 NM_001168338 NP_001161810
Function	Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells. {ECO:0000269|PubMed:14699093}.
Subcellular Location	Secreted {ECO:0000269|PubMed:10077593, ECO:0000269|PubMed:14699093}. Note=Locates to the cell surface where it is proteolytically cleaved to produce the active plasmin. Interaction with HRG tethers it to the cell surface.
Tissue Specificity	Present in plasma and many other extracellular fluids. It is synthesized in the liver.
Top Pathways	Complement and coagulation cascades, Staphylococcus aureus infection, Influenza A, Neuroactive ligand-receptor interaction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Angiostatin protein fragment - ab123771 from Abcam Category Protein Prices $192.00 Sizes 20 µg Source E. coli Species Human

Active human Plasmin full length protein - ab90928 from Abcam Category Protein Prices $356.00 Sizes 1 mg Source Native Species Human

Active human Plasmin full length protein - ab95112 from Abcam Category Protein Prices $450.00 Sizes 1 ml Source Native Species Human

Human Plasmin full length protein - ab92799 from Abcam Category Protein Prices $609.00 Sizes 1 mg Source Native Species Human

Active human Plasmin full length protein - ab84406 from Abcam Category Protein Prices $450.00 Sizes 1 mg Source Native Species Human

Active human Plasminogen full length protein - ab77879 from Abcam Category Protein Prices $356.00 Sizes 1 mg Source Native Species Human

Active human Plasminogen full length protein - ab92924 from Abcam Category Protein Prices $356.00 Sizes 1 mg Source Native Species Human

Active human Plasminogen full length protein - ab92770 from Abcam Category Protein Prices $356.00 Sizes 1 mg Source Native Species Human

Active human Plasminogen kringle 1 + 2 + 3 protein fragment - ab73645 from Abcam Category Protein Prices $239.00 Sizes 100 µg Source E. coli Species Human

Active human Plasminogen protein fragment - ab200264 from Abcam Category Protein Prices $101.00 Sizes 10 µg Source E. coli Species Human

Active rat Plasminogen full length protein - ab92874 from Abcam Category Protein Prices $450.00 Sizes 1 mg Source Native Species Rat

Chicken Plasminogen full length protein - ab92768 from Abcam Category Protein Prices $356.00 Sizes 1 mg Source Native Species Chicken

Cow Plasminogen full length protein - ab62500 from Abcam Category Protein Prices $285.00 Sizes 1 mg Source Native Species Bovine

Cow Plasminogen full length protein - ab168910 from Abcam Category Protein Prices $450.00 Sizes 1 mg Source Native Species Bovine

Dog Plasminogen full length protein - ab119821 from Abcam Category Protein Prices $609.00 Sizes 1 mg Source Native Species Dog

Human Plasmin full length protein - ab168868 from Abcam Category Protein Source Native Species Human

Human Plasmin full length protein - ab62416 from Abcam Category Protein Source Native Species Human

Human Plasminogen full length protein - ab159139 from Abcam Category Protein Source Wheat germ Species Human

Human Plasminogen full length protein - ab167783 from Abcam Category Protein Source Native Species Human

Human Plasminogen full length protein - ab62493 from Abcam Category Protein Source Native Species Human

Human Plasminogen full length protein - ab62559 from Abcam Category Protein Source Native Species Human

Human Plasminogen full length protein - ab62561 from Abcam Category Protein Source Native Species Human

Human Plasminogen full length protein - ab62565 from Abcam Category Protein Source Native Species Human

Human Plasminogen protein fragment - ab159140 from Abcam Category Protein Source Wheat germ Species Human

Mouse Plasminogen full length protein - ab168871 from Abcam Category Protein Source Native Species Mouse

Search more