VCP

Gene Symbol	VCP
Entrez Gene	7415
Alt Symbol	ALS14, HEL-220, HEL-S-70, IBMPFD, IBMPFD1, TERA, p97
Species	Human
Gene Type	protein-coding
Description	valosin containing protein
Other Description	15S Mg(2+)-ATPase p97 subunit|TER ATPase|epididymis luminal protein 220|epididymis secretory protein Li 70|transitional endoplasmic reticulum ATPase|valosin-containing protein|yeast Cdc48p homolog
Swissprots	B2R5T8 P55072 Q9UCD5 Q969G7 Q2TAI5 Q0V924
Accessions	AAC07984 CAH56816 EAW58403 EAW58404 P55072 AF100752 AAD43016 AF313485 AAG29873 AF313486 AAG29874 AI343015 AK307735 AK312310 BAG35235 AL137377 CAB70717 BC007562 AAH07562 BC012195 BC017171 BC096751 BC110913 AAI10914 BC121794 AAI21795 BC122550 AAI22551 DA880782 DB524539 FJ224344 ACI46036 FJ224352 ACI46044 Z70768 CAA94809 NM_007126 NP_009057
Function	Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A. Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmi
Subcellular Location	Cytoplasm, cytosol. Endoplasmic reticulum. Nucleus. Note=Present in the neuronal hyaline inclusion bodies specifically found in motor neurons from amyotrophic lateral sclerosis patients. Present in the Lewy bodies specifically found in neurons from Parkinson disease patients. Recruited to the cytoplasmic surface of the endoplasmic reticulum via interaction with AMFR/gp78. Following DNA double-strand breaks, recruited to the sites of damage. Recruited to stalled replication forks via interaction with SPRTN.
Top Pathways	Protein processing in endoplasmic reticulum, Legionellosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Rabbit anti-VCP Antibody, Affinity Purified - PLA0120 from Sigma-Aldrich Prices $323.50 Sizes 100 µl

Mouse/Human/Rat VCP ELISA Kit (Cell-Based ELISA) - LS-F2382 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 0.313-20 ng/ml

Mouse/Human/Rat Phospho-VCP (Ser352) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1748 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 0.313-20 ng/ml

Rat VCP ELISA Kit (Sandwich ELISA) - LS-F8665 from LifeSpan Bioscience Category ELISA Kit Prices $780.00 Sizes 1 plate Sensitivity 0.115 ng/ml Range 0.313-20 ng/ml

Human VCP ELISA Kit (Sandwich ELISA) - LS-F8719 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.112 ng/ml Range 0.313-20 ng/ml

Transitional endoplasmic reticulum ATPase (VCP), Human, ELISA Kit - CSB-EL025813HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Valosin Containing Protein (VCP), Human, ELISA Kit - SEC601Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.122ng/mL Range 0.312-20ng/mL

VCP Colorimetric Cell-Based ELISA Kit - CB5720 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

VCP (Phospho-Ser352) Colorimetric Cell-Based ELISA Kit - CBP1846 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

valosin-containing protein, ELISA Kit - MBS941726 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human VCP is typically less than 5.86 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 23.44 pg/ml -1500 pg/ml.

ELISA Kit for Valosin Containing Protein (VCP) - SEC601Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.112ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA’s were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

ELISA Kit for Valosin Containing Protein (VCP) - SEC601Ra from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.115ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA’s were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

Human Transitional endoplasmic reticulum ATPase(VCP) ELISA kit - CSB-EL025813HU from Cusabio Category ELISA Kit Sensitivity 5.86 pg/ml. Range 23.44 pg/ml-1500 pg/ml

ELISA Kit for Valosin Containing Protein (VCP) - SEC601Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.112ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA's were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

Human VCP ELISA Kit - abx153462 from Abbexa Category ELISA Kit Sensitivity 0.116 ng/ml Range 0.313 ng/ml - 20 ng/ml

Valosin Containing Protein (VCP), Human, ELISA Kit - DL-VCP-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 0.312-20 ng/mL

VCP ELISA Kit - DEIA-XYA1819 from Creative Diagnostics Category ELISA Kit

VCP (Phospho-Ser352) ELISA Kit - DEIA-XYA1820 from Creative Diagnostics Category ELISA Kit

Human VCP ELISA Kit - abx572940 from Abbexa Category ELISA Kit Sensitivity 0.122 ng/ml Range 0.313 ng/ml - 20 ng/ml

Human Transitional endoplasmic reticulum ATPase (VCP) ELISA Kit - EKC35861 from Biomatik Category ELISA Kit Prices $705.00, $2,820.00, $5,288.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 5.86 pg/ml Range 23.44 pg/ml-1500 pg/ml

Human VCP ELISA Kit - E100035 from Biobool Category ELISA Kit

VCP ELISA Kit (Human) (OKCD00874) - OKCD00874 from Aviva Systems Biology Category ELISA Kit Prices $545.00 Sizes 96 wells Sensitivity < 0.112 ng/mL Range 0.312-20 ng/mL

anti-VCP antibody - ARG55819 from Arigo Biolaboratories Category ELISA Kit

anti-VCP antibody - ARG55807 from Arigo Biolaboratories Category ELISA Kit

Human Transitional endoplasmic reticulum ATPase (VCP) ELISA Kit - AE11769HU from ARP American Research Products Category ELISA Kit Prices $549.00 Sizes 96 t Sensitivity 0.112 ng/mL Range 0.312-20 ng/mL

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