| Gene Symbol | VCP |
|---|---|
| Entrez Gene | 7415 |
| Alt Symbol | ALS14, HEL-220, HEL-S-70, IBMPFD, IBMPFD1, TERA, p97 |
| Species | Human |
| Gene Type | protein-coding |
| Description | valosin containing protein |
| Other Description | 15S Mg(2+)-ATPase p97 subunit|TER ATPase|epididymis luminal protein 220|epididymis secretory protein Li 70|transitional endoplasmic reticulum ATPase|valosin-containing protein|yeast Cdc48p homolog |
| Swissprots | B2R5T8 P55072 Q9UCD5 Q969G7 Q2TAI5 Q0V924 |
| Accessions | AAC07984 CAH56816 EAW58403 EAW58404 P55072 AF100752 AAD43016 AF313485 AAG29873 AF313486 AAG29874 AI343015 AK307735 AK312310 BAG35235 AL137377 CAB70717 BC007562 AAH07562 BC012195 BC017171 BC096751 BC110913 AAI10914 BC121794 AAI21795 BC122550 AAI22551 DA880782 DB524539 FJ224344 ACI46036 FJ224352 ACI46044 Z70768 CAA94809 NM_007126 NP_009057 |
| Function | Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A. Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmi |
| Subcellular Location | Cytoplasm, cytosol. Endoplasmic reticulum. Nucleus. Note=Present in the neuronal hyaline inclusion bodies specifically found in motor neurons from amyotrophic lateral sclerosis patients. Present in the Lewy bodies specifically found in neurons from Parkinson disease patients. Recruited to the cytoplasmic surface of the endoplasmic reticulum via interaction with AMFR/gp78. Following DNA double-strand breaks, recruited to the sites of damage. Recruited to stalled replication forks via interaction with SPRTN. |
| Top Pathways | Protein processing in endoplasmic reticulum, Legionellosis |
VCP CRISPR/Cas9 KO Plasmid (h) - sc-401052 from Santa Cruz Biotechnology
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VCP HDR Plasmid (h) - sc-401052-HDR from Santa Cruz Biotechnology
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VCP Double Nickase Plasmid (h) - sc-401052-NIC from Santa Cruz Biotechnology
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VCP Double Nickase Plasmid (h2) - sc-401052-NIC-2 from Santa Cruz Biotechnology
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VCP CRISPR Activation Plasmid (h) - sc-401052-ACT from Santa Cruz Biotechnology
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VCP CRISPR Activation Plasmid (h2) - sc-401052-ACT-2 from Santa Cruz Biotechnology
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VCP Lentiviral Activation Particles (h) - sc-401052-LAC from Santa Cruz Biotechnology
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VCP Lentiviral Activation Particles (h2) - sc-401052-LAC-2 from Santa Cruz Biotechnology
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VCP siRNA (h) - sc-37187 from Santa Cruz Biotechnology
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VCP shRNA Plasmid (h) - sc-37187-SH from Santa Cruz Biotechnology
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VCP shRNA (h) Lentiviral Particles - sc-37187-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU071991 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1321 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1321 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04609 from Sigma-Aldrich
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VCP siRNA (Human) - CRH5073 from Cohesion Biosciences
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p97/VCP RNAi - H00007415-R01 from Novus Biologicals
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VCP - MBS8201420 from MyBioSource
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shRNA set against Human VCP (NM_007126.3) - SHH442456 from Creative biogene
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Human VCP siRNA - orb265575 from Biorbyt
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VCP shRNA Plasmid (Human) - CHH5073 from Cohesion Biosciences
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VCP miRNA 3'UTR clone - MiUTR3H-03814 from Creative biogene
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