| Gene Symbol |
LBP
|
| Entrez Gene |
3929
|
| Alt Symbol |
BPIFD2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
lipopolysaccharide binding protein
|
| Other Description |
BPI fold containing family D, member 2|LPS-binding protein|lipopolysaccharide-binding protein
|
| Swissprots |
Q9H403 P18428 Q9UD66 O43438 Q92672 B2R938
|
| Accessions |
AAA66446 AAC39547 CAA67226 CAC10462 EAW76033 EAW76034 P18428 AF105067 AAD21962 AK313625 BAG36385 AY344471 AAR03787 BC022256 AAH22256 BQ028088 DQ891394 ABM82320 DQ894434 ABM85360 M35533 AAA59493 NM_004139 NP_004130
|
| Function |
Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria, and acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide. {ECO:0000269|PubMed:17481951, ECO:0000269|PubMed:24120359}.
|
| Subcellular Location |
Secreted {ECO:0000269|PubMed:24120359}.
|
| Tissue Specificity |
Detected in blood serum (at protein level). {ECO:0000269|PubMed:24120359}.
|
| Top Pathways |
Toll-like receptor signaling pathway, Salmonella infection, Tuberculosis
|