Gene Symbol | LBP |
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Entrez Gene | 3929 |
Alt Symbol | BPIFD2 |
Species | Human |
Gene Type | protein-coding |
Description | lipopolysaccharide binding protein |
Other Description | BPI fold containing family D, member 2|LPS-binding protein|lipopolysaccharide-binding protein |
Swissprots | Q9H403 P18428 Q9UD66 O43438 Q92672 B2R938 |
Accessions | AAA66446 AAC39547 CAA67226 CAC10462 EAW76033 EAW76034 P18428 AF105067 AAD21962 AK313625 BAG36385 AY344471 AAR03787 BC022256 AAH22256 BQ028088 DQ891394 ABM82320 DQ894434 ABM85360 M35533 AAA59493 NM_004139 NP_004130 |
Function | Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria, and acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide. {ECO:0000269|PubMed:17481951, ECO:0000269|PubMed:24120359}. |
Subcellular Location | Secreted {ECO:0000269|PubMed:24120359}. |
Tissue Specificity | Detected in blood serum (at protein level). {ECO:0000269|PubMed:24120359}. |
Top Pathways | Toll-like receptor signaling pathway, Salmonella infection, Tuberculosis |
LBP CRISPR/Cas9 KO Plasmid (h) - sc-402651 from Santa Cruz Biotechnology
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LBP HDR Plasmid (h) - sc-402651-HDR from Santa Cruz Biotechnology
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LBP Double Nickase Plasmid (h) - sc-402651-NIC from Santa Cruz Biotechnology
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LBP Double Nickase Plasmid (h2) - sc-402651-NIC-2 from Santa Cruz Biotechnology
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LBP CRISPR Activation Plasmid (h) - sc-402651-ACT from Santa Cruz Biotechnology
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LBP CRISPR Activation Plasmid (h2) - sc-402651-ACT-2 from Santa Cruz Biotechnology
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LBP Lentiviral Activation Particles (h) - sc-402651-LAC from Santa Cruz Biotechnology
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LBP Lentiviral Activation Particles (h2) - sc-402651-LAC-2 from Santa Cruz Biotechnology
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LBP siRNA (h) - sc-43890 from Santa Cruz Biotechnology
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LBP shRNA Plasmid (h) - sc-43890-SH from Santa Cruz Biotechnology
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LBP shRNA (h) Lentiviral Particles - sc-43890-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU119771 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11573 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11573 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02957 from Sigma-Aldrich
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LBP siRNA (Human) - CRH2661 from Cohesion Biosciences
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shRNA set against Human LBP (NM_004139.3) - SHH328735 from Creative biogene
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LBP shRNA Plasmid (Human) - CHH2661 from Cohesion Biosciences
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LBP miRNA 3'UTR clone - MiUTR3H-01327 from Creative biogene
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