SIAH1

Gene Symbol SIAH1
Entrez Gene 6477
Alt Symbol SIAH1A
Species Human
Gene Type protein-coding
Description siah E3 ubiquitin protein ligase 1
Other Description E3 ubiquitin-protein ligase SIAH1|seven in absentia homolog 1|siah-1a
Swissprots Q49A58 Q8IUQ4 A0FKF3 Q92880 O43269
Accessions CAC35542 EAW82726 EAW82727 Q8IUQ4 AB451253 BAG70067 AB451377 BAG70191 AK023458 AK094663 BAG52904 AK225895 AK313861 BAG36589 BC018193 BC035562 AAH35562 BC042550 AAH42550 BC044920 AAH44920 BX357983 BX647064 CAE46191 CN360509 DQ890990 ABM81916 DQ894167 ABM85093 EF026094 ABK15529 U63295 AAC12950 U76247 AAC51907 XM_006721246 XP_006721309 XM_011523279 XP_011521581 NM_001006610 NP_001006611 NM_003031 NP_003022
Function E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (ELL2, MYB, POU2AF1, PML and RBBP8), a cell surface receptor (DCC), the cell-surface receptor-type tyrosine kinase FLT3, the cytoplasmic signal transduction molecules (KLF10/TIEG1 and NUMB), an antiapoptotic protein (BAG1), a microtubule motor protein (KIF22), a protein involved in synaptic vesicle function in neurons (SYP), a structural protein (CTNNB1) and SNCAIP. Confers constitutive instability to HIPK2 through proteasomal
Subcellular Location Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Partially nuclear.
Tissue Specificity Widely expressed at a low level. Down- regulated in advanced hepatocellular carcinomas. {ECO:0000269|PubMed:12557228, ECO:0000269|PubMed:9403064}.
Top Pathways Wnt signaling pathway, p53 signaling pathway, Ubiquitin mediated proteolysis

Mouse/Human/Rat SIAH1/SIAH2 ELISA Kit (Cell-Based ELISA) - LS-F3248 from LifeSpan Bioscience

Category ELISA Kit
Prices $450.00
Sizes 1 plate

SIAH1 Colorimetric Cell-Based ELISA - CB6074 from Assay Biotechnology

Category ELISA Kit
Prices $380.00, $760.00, $1,140.00
Sizes 1 kit, 2 kits, 3 kits
Range > 5000 Cells

seven in absentia homolog 1 (Drosophila) , ELISA Kit - MBS9328780 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

SIAH1 ELISA Kit - DEIA-XYA1618 from Creative Diagnostics

Category ELISA Kit

Human SIAH1 ELISA Kit - E035004 from Biobool

Category ELISA Kit

anti-SIAH1 antibody - ARG63185 from Arigo Biolaboratories

Category ELISA Kit

SIAH1 Colorimetric Cell-Based ELISA Kit - EKA50898 from Biomatik

Category ELISA Kit
Prices $399.00
Sizes 96 tests
Sensitivity At least 5000 cells/well
Range Qualitative
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