SIAH1

Gene Symbol	SIAH1
Entrez Gene	6477
Alt Symbol	SIAH1A
Species	Human
Gene Type	protein-coding
Description	siah E3 ubiquitin protein ligase 1
Other Description	E3 ubiquitin-protein ligase SIAH1|seven in absentia homolog 1|siah-1a
Swissprots	Q49A58 Q8IUQ4 A0FKF3 Q92880 O43269
Accessions	CAC35542 EAW82726 EAW82727 Q8IUQ4 AB451253 BAG70067 AB451377 BAG70191 AK023458 AK094663 BAG52904 AK225895 AK313861 BAG36589 BC018193 BC035562 AAH35562 BC042550 AAH42550 BC044920 AAH44920 BX357983 BX647064 CAE46191 CN360509 DQ890990 ABM81916 DQ894167 ABM85093 EF026094 ABK15529 U63295 AAC12950 U76247 AAC51907 XM_006721246 XP_006721309 XM_011523279 XP_011521581 NM_001006610 NP_001006611 NM_003031 NP_003022
Function	E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (ELL2, MYB, POU2AF1, PML and RBBP8), a cell surface receptor (DCC), the cell-surface receptor-type tyrosine kinase FLT3, the cytoplasmic signal transduction molecules (KLF10/TIEG1 and NUMB), an antiapoptotic protein (BAG1), a microtubule motor protein (KIF22), a protein involved in synaptic vesicle function in neurons (SYP), a structural protein (CTNNB1) and SNCAIP. Confers constitutive instability to HIPK2 through proteasomal
Subcellular Location	Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Partially nuclear.
Tissue Specificity	Widely expressed at a low level. Down- regulated in advanced hepatocellular carcinomas. {ECO:0000269|PubMed:12557228, ECO:0000269|PubMed:9403064}.
Top Pathways	Wnt signaling pathway, p53 signaling pathway, Ubiquitin mediated proteolysis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SIAH1 full length protein - ab131838 from Abcam Category Protein Source Wheat germ Species Human

Human SIAH1 peptide - ab22876 from Abcam Category Peptide Species Human

Human SIAH1 protein fragment - ab131709 from Abcam Category Protein Source E. coli Species Human

SIAH1 Antibody Blocking Peptide - LS-E4144 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SIAH1 Antibody Blocking Peptide - LS-E12085 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SIAH1 Antibody Blocking Peptide - LS-E25290 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SIAH1 Antibody Blocking Peptide - LS-E13724 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SIAH1 Recombinant Protein - H00006477-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

SIAH1 Partial Recombinant Protein - H00006477-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

SIAH1 Protein - NBP2-23470 from Novus Biologicals Category Protein Species Human

SIAH1-Antibody-Center-Blocking-Peptide - BP16396c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human SIAH1 protein - orb169296 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Source E.coli

SIAH1 peptide - orb108408 from Biorbyt Category Peptide Prices $374.00 Sizes 50 μg

SIAH1 Blocking Peptide - 33R-5522 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SIAH1 Blocking Peptide - 33R-3086 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SIAH1 protein (His tag) - 80R-2413 from Fitzgerald Category Protein Prices $365.00 Sizes 50 µg Source E.coli

SIAH1 Peptide - AC21-0118-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

SIAH1 (90-282, His-tag) - AR50493PU-N from Acris Antibodies Category Protein Prices $1,010.00 Sizes 250 µg Source E. coli Species Human

SIAH1 (90-282, His-tag) - AR50493PU-S from Acris Antibodies Category Protein Prices $410.00 Sizes 50 µg Source E. coli Species Human

SIAH1 - H00006477-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

SIAH1 - H00006477-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

SIAH1 - H00006477-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

SIAH1 - H00006477-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

SIAH1 Control Peptide - AP05260CP-N from Acris Antibodies Category Peptide Prices $205.00 Sizes 50 µg

SIAH1, 90-282aa, Human, His tag, E.coli - 01-P1669 from ARP American Research Products Category Protein Prices $179.00, $449.00, $1,089.00 Sizes 10 µg, 50 µg, 250 µg Species Human

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