SIAH1

Gene Symbol	SIAH1
Entrez Gene	6477
Alt Symbol	SIAH1A
Species	Human
Gene Type	protein-coding
Description	siah E3 ubiquitin protein ligase 1
Other Description	E3 ubiquitin-protein ligase SIAH1|seven in absentia homolog 1|siah-1a
Swissprots	Q49A58 Q8IUQ4 A0FKF3 Q92880 O43269
Accessions	CAC35542 EAW82726 EAW82727 Q8IUQ4 AB451253 BAG70067 AB451377 BAG70191 AK023458 AK094663 BAG52904 AK225895 AK313861 BAG36589 BC018193 BC035562 AAH35562 BC042550 AAH42550 BC044920 AAH44920 BX357983 BX647064 CAE46191 CN360509 DQ890990 ABM81916 DQ894167 ABM85093 EF026094 ABK15529 U63295 AAC12950 U76247 AAC51907 XM_006721246 XP_006721309 XM_011523279 XP_011521581 NM_001006610 NP_001006611 NM_003031 NP_003022
Function	E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (ELL2, MYB, POU2AF1, PML and RBBP8), a cell surface receptor (DCC), the cell-surface receptor-type tyrosine kinase FLT3, the cytoplasmic signal transduction molecules (KLF10/TIEG1 and NUMB), an antiapoptotic protein (BAG1), a microtubule motor protein (KIF22), a protein involved in synaptic vesicle function in neurons (SYP), a structural protein (CTNNB1) and SNCAIP. Confers constitutive instability to HIPK2 through proteasomal
Subcellular Location	Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Partially nuclear.
Tissue Specificity	Widely expressed at a low level. Down- regulated in advanced hepatocellular carcinomas. {ECO:0000269|PubMed:12557228, ECO:0000269|PubMed:9403064}.
Top Pathways	Wnt signaling pathway, p53 signaling pathway, Ubiquitin mediated proteolysis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SIAH-1 CRISPR/Cas9 KO Plasmid (h) - sc-400781 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

SIAH-1 HDR Plasmid (h) - sc-400781-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

SIAH-1 Double Nickase Plasmid (h) - sc-400781-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

SIAH-1 Double Nickase Plasmid (h2) - sc-400781-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

SIAH-1 CRISPR Activation Plasmid (h) - sc-400781-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

SIAH-1 CRISPR Activation Plasmid (h2) - sc-400781-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

SIAH-1 Lentiviral Activation Particles (h) - sc-400781-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

SIAH-1 Lentiviral Activation Particles (h2) - sc-400781-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

SIAH-1 siRNA (h) - sc-37495 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

SIAH-1 shRNA Plasmid (h) - sc-37495-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

SIAH-1 shRNA (h) Lentiviral Particles - sc-37495-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

SIAH-1/2 siRNA (h) - sc-44102 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

SIAH-1/2 shRNA Plasmid (h) - sc-44102-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

SIAH-1/2 shRNA (h) Lentiviral Particles - sc-44102-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

SIAH1 RNAi - H00006477-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

SIAH1 RNAi - H00006477-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU071391 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN19320 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19320 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR07732 from Sigma-Aldrich Category miRNA

SIAH1 siRNA (Human) - CRH4378 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

SIAH1 - MBS8204412 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human SIAH1 (NM_003031.3) - SHH407332 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human SIAH1(NM_001006610.1) - SHR224842 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human SIAH1(NM_003031.3) - SHR224950 from Creative biogene Category siRNA Species Reactivities Human

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