| Gene Symbol |
CBR4
|
| Entrez Gene |
84869
|
| Alt Symbol |
SDR45C1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
carbonyl reductase 4
|
| Other Description |
3-oxoacyl-[acyl-carrier-protein] reductase|carbonic reductase 4|carbonyl reductase family member 4|quinone reductase CBR4|short chain dehydrogenase/reductase family 45C member 1|short chain dehydrogenase/reductase family 45C, member 1
|
| Swissprots |
Q8WTW8 Q8N4T8 Q96K93
|
| Accessions |
CBF61666 CBU86558 EAX04797 EAX04798 Q8N4T8 AK027337 BAB55045 AK291756 BAF84445 AL049442 AL833393 CAH10582 AV704400 BC021973 AAH21973 BC033650 AAH33650 BG119539 BQ230058 DA217727 HQ447088 ADQ31575 W70279 XM_005263315 XP_005263372 XM_005263316 XP_005263373 XM_006714391 XP_006714454 XM_006714392 XP_006714455 XM_011532385 XP_011530687 XM_011532386 XP_011530688 XR_938789 NM_032783 NP_116172
|
| Function |
The heteroteramer with HSD17B8 has NADH-dependent 3- ketoacyl-acyl carrier protein reductase activity. May play a role in biosynthesis of fatty acids in mitochondria. The homotetramer may act as NADPH-dependent quinone reductase. Has broad substrate specificity and reduces 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones (in vitro). {ECO:0000269|PubMed:19000905, ECO:0000269|PubMed:19571038}.
|
| Subcellular Location |
Mitochondrion matrix {ECO:0000269|PubMed:19000905, ECO:0000269|PubMed:19571038}.
|
| Tissue Specificity |
Detected in liver and kidney (at protein level). {ECO:0000269|PubMed:19000905}.
|
![Western Blot: CBR4 Overexpression Lysate (Adult Normal) [NBP2-05968] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CBR4.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6616_CBR4%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-05968-img0001.jpg)