Gene Symbol | CBR4 |
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Entrez Gene | 84869 |
Alt Symbol | SDR45C1 |
Species | Human |
Gene Type | protein-coding |
Description | carbonyl reductase 4 |
Other Description | 3-oxoacyl-[acyl-carrier-protein] reductase|carbonic reductase 4|carbonyl reductase family member 4|quinone reductase CBR4|short chain dehydrogenase/reductase family 45C member 1|short chain dehydrogenase/reductase family 45C, member 1 |
Swissprots | Q8WTW8 Q8N4T8 Q96K93 |
Accessions | CBF61666 CBU86558 EAX04797 EAX04798 Q8N4T8 AK027337 BAB55045 AK291756 BAF84445 AL049442 AL833393 CAH10582 AV704400 BC021973 AAH21973 BC033650 AAH33650 BG119539 BQ230058 DA217727 HQ447088 ADQ31575 W70279 XM_005263315 XP_005263372 XM_005263316 XP_005263373 XM_006714391 XP_006714454 XM_006714392 XP_006714455 XM_011532385 XP_011530687 XM_011532386 XP_011530688 XR_938789 NM_032783 NP_116172 |
Function | The heteroteramer with HSD17B8 has NADH-dependent 3- ketoacyl-acyl carrier protein reductase activity. May play a role in biosynthesis of fatty acids in mitochondria. The homotetramer may act as NADPH-dependent quinone reductase. Has broad substrate specificity and reduces 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones (in vitro). {ECO:0000269|PubMed:19000905, ECO:0000269|PubMed:19571038}. |
Subcellular Location | Mitochondrion matrix {ECO:0000269|PubMed:19000905, ECO:0000269|PubMed:19571038}. |
Tissue Specificity | Detected in liver and kidney (at protein level). {ECO:0000269|PubMed:19000905}. |
CBR4 CRISPR/Cas9 KO Plasmid (h) - sc-413712 from Santa Cruz Biotechnology
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CBR4 HDR Plasmid (h) - sc-413712-HDR from Santa Cruz Biotechnology
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CBR4 Double Nickase Plasmid (h) - sc-413712-NIC from Santa Cruz Biotechnology
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CBR4 Double Nickase Plasmid (h2) - sc-413712-NIC-2 from Santa Cruz Biotechnology
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CBR4 CRISPR Activation Plasmid (h) - sc-413712-ACT from Santa Cruz Biotechnology
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CBR4 CRISPR Activation Plasmid (h2) - sc-413712-ACT-2 from Santa Cruz Biotechnology
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CBR4 Lentiviral Activation Particles (h) - sc-413712-LAC from Santa Cruz Biotechnology
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CBR4 Lentiviral Activation Particles (h2) - sc-413712-LAC-2 from Santa Cruz Biotechnology
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CBR4 siRNA (h) - sc-88976 from Santa Cruz Biotechnology
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CBR4 shRNA Plasmid (h) - sc-88976-SH from Santa Cruz Biotechnology
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CBR4 shRNA (h) Lentiviral Particles - sc-88976-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN5418 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5418 from Sigma-Aldrich
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CBR4 siRNA (Human) - CRJ3652 from Cohesion Biosciences
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CBR4 - MBS8237957 from MyBioSource
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shRNA set against Human CBR4 (NM_032783.4) - SHH255433 from Creative biogene
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CBR4 shRNA Plasmid (Human) - CHJ3652 from Cohesion Biosciences
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CBR4 miRNA 3'UTR clone - MiUTR4H-TG01659 from Creative biogene
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