AKR1C1

Gene Symbol AKR1C1
Entrez Gene 1645
Alt Symbol 2-ALPHA-HSD, 20-ALPHA-HSD, C9, DD1, DD1/DD2, DDH, DDH1, H-37, HAKRC, HBAB, MBAB
Species Human
Gene Type protein-coding
Description aldo-keto reductase family 1, member C1
Other Description 20 alpha-hydroxysteroid dehydrogenase|20-alpha-hydroxysteroid dehydrogenase|aldo-keto reductase C|aldo-keto reductase family 1 member C1|chlordecone reductase homolog HAKRC|dihydrodiol dehydrogenase 1|dihydrodiol dehydrogenase 1/2|dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase|dihydrodiol dehydrogenase isoform DD1|hepatic dihydrodiol dehydrogenase|high-affinity hepatic bile acid-binding protein|indanol dehydrogenase|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase|type II 3-alpha-hydroxysteroid dehydrogenase
Swissprots Q9UCX2 P52896 Q5SR15 Q7M4N2 Q04828
Accessions AAA18115 BAA92886 Q04828 AB031083 BAA92883 AK303435 BAG64483 AK310658 BC015490 AAH15490 BC020216 AAH20216 BC040210 AAH40210 BM923712 BT007197 AAP35861 CB119749 D26124 BAA05121 DQ891484 ABM82410 DQ893923 ABM84849 M86609 AAB02880 S68290 AAD14012 U05684 AAA16227 NM_001353 NP_001344
Function Converts progesterone to its inactive form, 20-alpha- dihydroxyprogesterone (20-alpha-OHP). In the liver and intestine, may have a role in the transport of bile. May have a role in monitoring the intrahepatic bile acid concentration. Has a low bile-binding ability. May play a role in myelin formation. {ECO:0000269|PubMed:11013348, ECO:0000269|PubMed:8573067}.
Subcellular Location Cytoplasm.
Tissue Specificity Expressed in all tissues tested including liver, prostate, testis, adrenal gland, brain, uterus, mammary gland and keratinocytes. Highest levels found in liver, mammary gland and brain. {ECO:0000269|PubMed:11013348}.
Top Pathways Steroid hormone biosynthesis, Metabolism of xenobiotics by cytochrome P450

DD1/2/3 (G-3) - sc-398421 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
DD1/2/3 (G-3): sc-398421. Western blot analysis of DD1/2/3 expression in Hep G2 (A) and A549 (B) whole cell lysates and human liver tissue extract (C).

Anti-AKR1C1/AKR1C2 antibody - ab96087 from Abcam

Prices $384.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-AKR1C1/AKR1C2 antibody (ab96087) at 1/1000 dilution + Raji whole cell lysate at 30 µg

Anti-AKR1C1/AKR1C2 antibody - ab72576 from Abcam

Prices $378.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-AKR1C1/AKR1C2 antibody (ab72576) at 1/500 dilution + Human liver tissue lysate at 50 µgSecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/5000 dilutiondeveloped using the ECL technique

Anti-AKR1C1/AKR1C2 antibody - ab92521 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-AKR1C1/AKR1C2 antibody (ab92521) at 1/500 dilutionLane 1 : COLO cell extractsLane 2 : COLO cell extracts with immunising peptide at 10 µgLysates/proteins at 30 µg per lane.

Anti-AKR1C1/AKR1C2 antibody - ab88312 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-AKR1C1/AKR1C2 antibody (ab88312) at 1 µg/mlLane 1 : transfected 293T cell lysateLane 2 : untransfected 293T cell lysateLysates/proteins at 25 µg per lane.Secondarygoat anti-mouse IgG at 1/5000 dilution

Anti-AKR1C1/AKR1C2 antibody - ab54807 from Abcam

Prices $378.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab54807 AKR1C2 antibody at 1ug/ml.

Anti-AKR1C1/AKR1C2 antibody [4B6AF3] - ab131375 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4B6AF3
All lanes : Anti-AKR1C1/AKR1C2 antibody [4B6AF3] (ab131375) at 2 µg/mlLane 1 : Molecular weight marker Lane 2 : HeLa Cell Lysate at 15 µgLane 3 : HepG2 Cell Lysate at 15 µgLane 4 : Human Liver Homogenate (HLH) at 10 µgLane 5 : Human Heart Homogenate (HHH) at 10 µgLane 6 : Mouse Liver Homogenate (MLH) at 10 µgLane 7 : Rat Liver Homogenate (RLH) at 10 µgLane 8 : Rat Heart Homogenate (RHH) at 10 µgSecondaryGoat anti-Mouse AP at 1/3000 dilution

Anti-AKR1C1/AKR1C2 antibody [4B6AF3] (Alexa Fluor® 488) - ab198598 from Abcam

Prices $425.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4B6AF3
ab198598 staining AKR1C1/AKR1C2 in HeLa cells. The cells were fixed with 100% methanol (5 min), permeabilized with 0.1% Triton X-100 for 5 minutes and then blocked with 1% BSA/10% normal goat serum/0.3M glycine in 0.1% PBS-Tween for 1h. The cells were then incubated overnight at +4°C with ab198598 at 1/50 dilution (shown in green) and ab195889, Mouse monoclonal to alpha Tubulin (Alexa Fluor® 594), at 1/250 dilution (shown in red). Nuclear DNA was labelled with DAPI (shown in blue).Image was taken with a confocal microscope (Leica-Microsystems, TCS SP8).

Anti-AKR1C1/AKR1C2 antibody [4B6AF3] (Alexa Fluor® 647) - ab198409 from Abcam

Prices $425.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4B6AF3
ab198409 staining HuntingtinAKR1C1/AKR1C2 in HeLa cells. The cells were fixed with 100% methanol (5 min), permeabilised in 0.1% Triton X-100 for 5 minutes and then blocked in 1% BSA/10% normal goat serum/0.3M glycine in 0.1% PBS-Tween for 1h. The cells were then incubated with ab198409 at 1/50 dilution (shown in red) and ab195887, Mouse monoclonal [DM1A] to alpha Tubulin (Alexa Fluor® 488, shown in green) at 1/167 dilution overnight at +4°C. Nuclear DNA was labelled in blue with DAPI.Image was taken with a confocal microscope (Leica-Microsystems, TCS SP8).

Anti-AKR1C1/AKR1C2 antibody [AT6D10] - ab112555 from Abcam

Prices $376.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone AT6D10
Lane 1 : Anti-AKR1C1/AKR1C2 antibody [AT6D10] (ab112555) at 1/500 dilutionLane 2 : Anti-AKR1C1/AKR1C2 antibody [AT6D10] (ab112555) at 1/1000 dilutionLane 3 : Anti-AKR1C1/AKR1C2 antibody [AT6D10] (ab112555) at 1/5000 dilutionLane 1 : HepG2 cell extractLane 2 : HepG2 cell extractLane 3 : HepG2 cell extractLysates/proteins at 33 µg per lane.developed using the ECL technique

Anti-AKR1C1/AKR1C2 antibody [EPR11541(B)] - ab166900 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR11541(B)
All lanes : Anti-AKR1C1/AKR1C2 antibody [EPR11541(B)] (ab166900) at 1/1000 dilutionLane 1 : U87 MG lysateLane 2 : HepG2 cell lysateLysates/proteins at 10 µg per lane.Secondarygoat anti-rabbit HRP antibody at 1/2000 dilution

Anti-AKR1C1/AKR1C2 antibody [EPR11542] - ab179448 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR11542
Western blot analysis on immunoprecipitation pellet from HepG2 cell lysate immunoprecipitated using ab179448 at 1/10 dilution.

Anti-AKR1C1/AKR1C2 antibody - C-terminal - ab170613 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-AKR1C1/AKR1C2 antibody - C-terminal (ab170613) at 1/100 dilution + HepG2 cell line lysate at 35 µg

Anti-AKR1C1 antibody - ab192785 from Abcam

Prices $407.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-AKR1C1 antibody (ab192785) at 1/1000 dilution + Raji whole cell lysate at 30 µg

Anti-AKR1C1 antibody - C-terminal - ab183078 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue labeling AKR1C1 with ab183078 at a 1/30 dilution, in the presence (right panel) or absence (left panel) of immunizing peptide.

Anti-DDH / AKR1C1 Antibody - LS-C306183 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-DDH / AKR1C1 Antibody - LS-C309388 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-DDH / AKR1C1 Antibody (clone 1B3) - LS-C197032 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1B3
AKR1C1 monoclonal antibody (M01), clone 1B3. Western Blot analysis of AKR1C1 expression in HeLa.

Anti-DDH / AKR1C1 Antibody (aa2-218) - LS-C178570 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DDH / AKR1C1 Antibody (aa22-248) IHC-plus™ - LS-B10819 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-DDH / AKR1C1 antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B10819 concentration 7.5 ug/ml.

Anti-DDH / AKR1C1 Antibody - LS-C309391 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DDH / AKR1C1 Antibody (clone AT6D10) IHC-plus™ - LS-B6269 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone AT6D10
Anti-AKR1C1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6269 concentration 10 ug/ml.

Anti-DDH / AKR1C1 Antibody (aa50-99) IHC-plus™ - LS-B12017 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-DDH / AKR1C1 Antibody (aa99-148) IHC-plus™ - LS-B12016 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-DDH / Dihydrodiol Dehydrogenase Antibody - LS-C26685 from LifeSpan Bioscience

Prices $470.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Left: Immunoperoxidase staining of formalin-fixed paraffin embedded human lung cancer tissue showing cytoplasmic localization of dihydrodiol dehydrogenase. Right: Western blot of DDH antibody (LS-C26685) on porcine liver (A) and breast cancer (B).
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