| Gene Symbol |
AKR1C1
|
| Entrez Gene |
1645
|
| Alt Symbol |
2-ALPHA-HSD, 20-ALPHA-HSD, C9, DD1, DD1/DD2, DDH, DDH1, H-37, HAKRC, HBAB, MBAB
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
aldo-keto reductase family 1, member C1
|
| Other Description |
20 alpha-hydroxysteroid dehydrogenase|20-alpha-hydroxysteroid dehydrogenase|aldo-keto reductase C|aldo-keto reductase family 1 member C1|chlordecone reductase homolog HAKRC|dihydrodiol dehydrogenase 1|dihydrodiol dehydrogenase 1/2|dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase|dihydrodiol dehydrogenase isoform DD1|hepatic dihydrodiol dehydrogenase|high-affinity hepatic bile acid-binding protein|indanol dehydrogenase|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase|type II 3-alpha-hydroxysteroid dehydrogenase
|
| Swissprots |
Q9UCX2 P52896 Q5SR15 Q7M4N2 Q04828
|
| Accessions |
AAA18115 BAA92886 Q04828 AB031083 BAA92883 AK303435 BAG64483 AK310658 BC015490 AAH15490 BC020216 AAH20216 BC040210 AAH40210 BM923712 BT007197 AAP35861 CB119749 D26124 BAA05121 DQ891484 ABM82410 DQ893923 ABM84849 M86609 AAB02880 S68290 AAD14012 U05684 AAA16227 NM_001353 NP_001344
|
| Function |
Converts progesterone to its inactive form, 20-alpha- dihydroxyprogesterone (20-alpha-OHP). In the liver and intestine, may have a role in the transport of bile. May have a role in monitoring the intrahepatic bile acid concentration. Has a low bile-binding ability. May play a role in myelin formation. {ECO:0000269|PubMed:11013348, ECO:0000269|PubMed:8573067}.
|
| Subcellular Location |
Cytoplasm.
|
| Tissue Specificity |
Expressed in all tissues tested including liver, prostate, testis, adrenal gland, brain, uterus, mammary gland and keratinocytes. Highest levels found in liver, mammary gland and brain. {ECO:0000269|PubMed:11013348}.
|
| Top Pathways |
Steroid hormone biosynthesis, Metabolism of xenobiotics by cytochrome P450
|