AKR1C1

Gene Symbol	AKR1C1
Entrez Gene	1645
Alt Symbol	2-ALPHA-HSD, 20-ALPHA-HSD, C9, DD1, DD1/DD2, DDH, DDH1, H-37, HAKRC, HBAB, MBAB
Species	Human
Gene Type	protein-coding
Description	aldo-keto reductase family 1, member C1
Other Description	20 alpha-hydroxysteroid dehydrogenase|20-alpha-hydroxysteroid dehydrogenase|aldo-keto reductase C|aldo-keto reductase family 1 member C1|chlordecone reductase homolog HAKRC|dihydrodiol dehydrogenase 1|dihydrodiol dehydrogenase 1/2|dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase|dihydrodiol dehydrogenase isoform DD1|hepatic dihydrodiol dehydrogenase|high-affinity hepatic bile acid-binding protein|indanol dehydrogenase|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase|type II 3-alpha-hydroxysteroid dehydrogenase
Swissprots	Q9UCX2 P52896 Q5SR15 Q7M4N2 Q04828
Accessions	AAA18115 BAA92886 Q04828 AB031083 BAA92883 AK303435 BAG64483 AK310658 BC015490 AAH15490 BC020216 AAH20216 BC040210 AAH40210 BM923712 BT007197 AAP35861 CB119749 D26124 BAA05121 DQ891484 ABM82410 DQ893923 ABM84849 M86609 AAB02880 S68290 AAD14012 U05684 AAA16227 NM_001353 NP_001344
Function	Converts progesterone to its inactive form, 20-alpha- dihydroxyprogesterone (20-alpha-OHP). In the liver and intestine, may have a role in the transport of bile. May have a role in monitoring the intrahepatic bile acid concentration. Has a low bile-binding ability. May play a role in myelin formation. {ECO:0000269|PubMed:11013348, ECO:0000269|PubMed:8573067}.
Subcellular Location	Cytoplasm.
Tissue Specificity	Expressed in all tissues tested including liver, prostate, testis, adrenal gland, brain, uterus, mammary gland and keratinocytes. Highest levels found in liver, mammary gland and brain. {ECO:0000269|PubMed:11013348}.
Top Pathways	Steroid hormone biosynthesis, Metabolism of xenobiotics by cytochrome P450

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human AKR1C1 full length protein - ab168012 from Abcam Category Protein Prices $410.00 Sizes 100 µg Source E. coli Species Human

Active human AKR1C1 full length protein - ab117472 from Abcam Category Protein Prices $192.00 Sizes 5 µg Source E. coli Species Human

Human AKR1C1 full length protein - ab93730 from Abcam Category Protein Prices $188.00, $692.00 Sizes 100 µg, 500 µg Source E. coli Species Human

DDH / AKR1C1 Antibody Blocking Peptide - LS-E22031 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Aldo-keto Reductase 1C1/AKR1C1 Protein - NBP1-41223 from Novus Biologicals Category Protein Prices $279.00 Sizes 100 µg Species Human

Aldo-keto Reductase 1C1/AKR1C1 Recombinant Protein - H00001645-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Aldo-keto Reductase 1C1/AKR1C1 Partial Recombinant Protein - H00001645-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Aldo-keto Reductase 1C1/AKR1C1 Recombinant Protein - P3501 from Novus Biologicals Category Protein Prices $449.00 Sizes 100 µg Species Human

AKR1C1-Antibody-C-term-Blocking-Peptide - BP14485b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

AKR1C1-Antibody-Center-Blocking-peptide - BP5331c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human Aldo-keto Reductase 1C1/AKR1C1, CF - 6529-DH-020 from R&D Systems Category Protein Source E. coli-derived, Met1-Tyr323

AKR1C1 Protein (OPPA02257) - OPPA02257 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

Human Aldo-Keto Reductase Family Member C1 protein - orb90022 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E.coli

AKR1C1 Blocking Peptide - 33R-4926 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

AKR1C1 Blocking Peptide - 33R-2154 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

AKR1C1 protein (His tag) - 80R-1267 from Fitzgerald Category Protein Prices $220.00 Sizes 100 µg Source E.coli

AKR1C1 Blocking Peptide - abx062094 from Abbexa Category Peptide Species Human, Mouse, Rat

Human AK1C1 Protein - abx060037 from Abbexa Category Protein Source Yeast Species Human

AKR1C1 / DHH1 (1-323, His-tag) - AR09395PU-L from Acris Antibodies Category Protein Prices $695.00 Sizes 500 µg Source E. coli Species Human

AKR1C1 / DHH1 (1-323, His-tag) - AR09395PU-N from Acris Antibodies Category Protein Prices $305.00 Sizes 100 µg Source E. coli Species Human

AKR1C1 / DHH1 - H00001645-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

AKR1C1 / DHH1 - H00001645-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

AKR1C1 / DHH1 - H00001645-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

AKR1C1 / DHH1 - H00001645-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

AKR1C1 / DHH1 - P3501 from Acris Antibodies Category Protein Prices $430.00 Sizes 100 µg Species Human

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