| Gene Symbol |
PTK2
|
| Entrez Gene |
396416
|
| Alt Symbol |
FAK, FRNK, p125FAK
|
| Species |
Chicken
|
| Gene Type |
protein-coding
|
| Description |
protein tyrosine kinase 2
|
| Other Description |
FADK 1|PTK2 protein tyrosine kinase 2|focal adhesion kinase 1|focal adhesion kinase-related nonkinase|p41/p43FRNK|pp125FAK|protein-tyrosine kinase 2
|
| Swissprots |
Q00944
|
| Accessions |
Q00944 L07415 AAA48773 L08402 AAA48766 M86656 AAA48765 NM_205435 NP_990766
|
| Function |
Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development, embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), ephrin receptors, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, cre
|
| Subcellular Location |
Cell junction, focal adhesion {ECO:0000269|PubMed:8423801}. Cell membrane {ECO:0000269|PubMed:8423801}; Peripheral membrane protein {ECO:0000269|PubMed:8423801}; Cytoplasmic side {ECO:0000269|PubMed:8423801}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:8423801}. Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Nucleus {ECO:0000269|PubMed:8423801}. Note=Constituent of focal adhesions. Detected at microtubules (By similarity). {ECO:0000250}.
|
| Top Pathways |
VEGF signaling pathway, Focal adhesion, ErbB signaling pathway, Regulation of actin cytoskeleton
|