PTK2

Gene Symbol	PTK2
Entrez Gene	396416
Alt Symbol	FAK, FRNK, p125FAK
Species	Chicken
Gene Type	protein-coding
Description	protein tyrosine kinase 2
Other Description	FADK 1|PTK2 protein tyrosine kinase 2|focal adhesion kinase 1|focal adhesion kinase-related nonkinase|p41/p43FRNK|pp125FAK|protein-tyrosine kinase 2
Swissprots	Q00944
Accessions	Q00944 L07415 AAA48773 L08402 AAA48766 M86656 AAA48765 NM_205435 NP_990766
Function	Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development, embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), ephrin receptors, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, cre
Subcellular Location	Cell junction, focal adhesion {ECO:0000269|PubMed:8423801}. Cell membrane {ECO:0000269|PubMed:8423801}; Peripheral membrane protein {ECO:0000269|PubMed:8423801}; Cytoplasmic side {ECO:0000269|PubMed:8423801}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:8423801}. Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Nucleus {ECO:0000269|PubMed:8423801}. Note=Constituent of focal adhesions. Detected at microtubules (By similarity). {ECO:0000250}.
Top Pathways	VEGF signaling pathway, Focal adhesion, ErbB signaling pathway, Regulation of actin cytoskeleton

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

Anti-FAK (phospho S722) antibody - ab4790 from Abcam Prices $370.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

Anti-FAK (phospho S732) antibody - ab4792 from Abcam Prices $401.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

Anti-FAK (phospho S910) antibody - ab4794 from Abcam Prices $370.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

Anti-FAK (phospho Y397) antibody - ab39967 from Abcam Prices $379.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-FAK (phospho Y407) antibody - ab4814 from Abcam Prices $370.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

Anti-FAK (phospho Y576) antibody - ab4815 from Abcam Prices $370.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

Anti-FAK (phospho Y577) antibody - ab4798 from Abcam Prices $370.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

Anti-FAK (phospho Y861) antibody - ab4804 from Abcam Prices $379.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

Anti-FAK (phospho Y861) antibody - ab200811 from Abcam Prices $359.00 Sizes 10 tests Host Rabbit Clonality Polyclonal

Anti-FAK antibody [0.T.43] - ab33141 from Abcam Host Mouse Clonality Monoclonal Clone 0.T.43

Anti-FAK antibody (Biotin) - ab192940 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

PTK2 Antibody (OACA01987) - OACA01987 from Aviva Systems Biology Prices $270.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

PTK2 Antibody (OACA01988) - OACA01988 from Aviva Systems Biology Prices $270.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

PTK2 Antibody (OACA01989) - OACA01989 from Aviva Systems Biology Prices $270.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

PTK2 Antibody (OACA01990) - OACA01990 from Aviva Systems Biology Prices $270.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti -FAK (Focal Adhesion Associated Protein Tyrosine Kinase, BC3) - F0019-57 from USBiological Life Science Host Rabbit Clonality Polyclonal

Anti -FAK (Focal Adhesion Associated Protein Tyrosine Kinase, BC3) - F0019-55 from USBiological Life Science Host Mouse Clonality Monoclonal Clone 0.T.43

Chicken Focal adhesion kinase 1 Antibody - abx109644 from Abbexa Prices $490.00, $490.00, $490.00, $490.00 Sizes 10 μl, 50 μl, 100 μl, 200 μl Host Rabbit Clonality Polyclonal

Chicken Focal adhesion kinase 1 Antibody (Biotin) - abx105258 from Abbexa Prices $490.00, $490.00, $490.00, $490.00 Sizes 10 μl, 50 μl, 100 μl, 200 μl Host Rabbit Clonality Polyclonal

Chicken Focal adhesion kinase 1 Antibody (FITC) - abx106676 from Abbexa Prices $490.00, $490.00, $490.00, $490.00 Sizes 10 μl, 50 μl, 100 μl, 200 μl Host Rabbit Clonality Polyclonal

Chicken Focal adhesion kinase 1 Antibody (HRP) - abx108093 from Abbexa Prices $490.00, $490.00, $490.00, $490.00 Sizes 10 μl, 50 μl, 100 μl, 200 μl Host Rabbit Clonality Polyclonal

Focal adhesion kinase 1, Polyclonal Antibody - MBS1490139 from MyBioSource Prices $160.00, $235.00 Sizes 50 µg, 100 µg Host Rabbit Clonality Polyclonal

Focal adhesion kinase 1, Polyclonal Antibody - MBS1490842 from MyBioSource Prices $160.00, $235.00 Sizes 50 µg, 100 µg Host Rabbit Clonality Polyclonal

Focal adhesion kinase 1, Polyclonal Antibody - MBS1491132 from MyBioSource Prices $160.00, $235.00 Sizes 50 µg, 100 µg Host Rabbit Clonality Polyclonal

Focal adhesion kinase 1, Polyclonal Antibody - MBS1489104 from MyBioSource Prices $160.00, $235.00 Sizes 50 µg, 100 µg Host Rabbit Clonality Polyclonal

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