Gene Symbol | BLOC1S3 |
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Entrez Gene | 388552 |
Alt Symbol | BLOS3, HPS8, RP |
Species | Human |
Gene Type | protein-coding |
Description | biogenesis of lysosomal organelles complex-1, subunit 3 |
Other Description | BLOC-1 subunit 3|biogenesis of lysosome-related organelles complex 1 subunit 3|biogenesis of lysosome-related organelles complex-1, subunit 3|reduced pigmentation, mouse, homolog of |
Swissprots | B2RXB8 Q6QNY0 |
Accessions | Q6QNY0 AK130151 AK130186 BAC85300 AK296695 BAG59289 AY531266 AAT00462 BC151151 AAI51152 BC151152 AAI51153 BU616355 DC422050 DN996082 LN608738 XM_011526952 XP_011525254 XR_935826 XR_935827 XR_935828 XR_935829 NM_212550 NP_997715 |
Function | Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking. {ECO:0000269|PubMed:16385460, ECO:0000269|PubMed:17182842}. |
Subcellular Location | Cytoplasm {ECO:0000250}. |
BLOS3 CRISPR/Cas9 KO Plasmid (h) - sc-415788 from Santa Cruz Biotechnology
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BLOS3 HDR Plasmid (h) - sc-415788-HDR from Santa Cruz Biotechnology
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BLOS3 Double Nickase Plasmid (h) - sc-415788-NIC from Santa Cruz Biotechnology
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BLOS3 Double Nickase Plasmid (h2) - sc-415788-NIC-2 from Santa Cruz Biotechnology
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BLOS3 CRISPR Activation Plasmid (h) - sc-415788-ACT from Santa Cruz Biotechnology
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BLOS3 CRISPR Activation Plasmid (h2) - sc-415788-ACT-2 from Santa Cruz Biotechnology
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BLOS3 Lentiviral Activation Particles (h) - sc-415788-LAC from Santa Cruz Biotechnology
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BLOS3 Lentiviral Activation Particles (h2) - sc-415788-LAC-2 from Santa Cruz Biotechnology
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BLOS3 siRNA (h) - sc-97284 from Santa Cruz Biotechnology
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BLOS3 shRNA Plasmid (h) - sc-97284-SH from Santa Cruz Biotechnology
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BLOS3 shRNA (h) Lentiviral Particles - sc-97284-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN3992 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3992 from Sigma-Aldrich
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BLOC1S3 siRNA (Human) - CRJ7807 from Cohesion Biosciences
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BLOC1S3 - MBS8201347 from MyBioSource
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shRNA set against Human Bloc1s3 (NM_212550.3) - SHH246926 from Creative biogene
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Human BLOC1S3 siRNA - orb278308 from Biorbyt
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BLOC1S3 shRNA Plasmid (Human) - CHJ7807 from Cohesion Biosciences
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BLOC1S3 miRNA 3'UTR clone - MiUTR3H-10788 from Creative biogene
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