PRICKLE1

Gene Symbol PRICKLE1
Entrez Gene 144165
Alt Symbol EPM1B, RILP
Species Human
Gene Type protein-coding
Description prickle homolog 1 (Drosophila)
Other Description REST (RE-1 silencing transcription factor)/NRSF (neuron-restrictive silencer factor)-interacting LIM domain protein|REST/NRSF-interacting LIM domain protein 1|prickle-like 1|prickle-like protein 1
Swissprots Q14C83 Q71QF8 Q96N00 Q96MT3
Accessions EAW57854 EAW57855 Q96MT3 AF399844 AAQ03035 AF543759 AAQ11824 AF543760 AAQ11825 AK056189 BAB71116 AK056499 BAB71198 AK122877 BAG53775 AK122881 BAG53778 BC042722 BC114939 AAI14940 BC114940 AAI14941 BE858932 CN390789 DA321918 DA413584 XM_011537946 XP_011536248 XM_011537947 XP_011536249 NM_001144881 NP_001138353 NM_001144882 NP_001138354 NM_001144883 NP_001138355 NM_153026 NP_694571
Function Involved in the planar cell polarity pathway that controls convergent extension during gastrulation and neural tube closure. Convergent extension is a complex morphogenetic process during which cells elongate, move mediolaterally, and intercalate between neighboring cells, leading to convergence toward the mediolateral axis and extension along the anteroposterior axis. Necessary for nuclear localization of REST. May serve as nuclear receptor. {ECO:0000269|PubMed:21901791}.
Subcellular Location Nucleus membrane {ECO:0000269|PubMed:14645515}. Cytoplasm, cytosol {ECO:0000269|PubMed:14645515}. Note=A smaller amount is detected in the cytosol.
Tissue Specificity Expressed at highest levels in placenta and at lower levels in lung, liver, kidney and pancreas. Expressed in thalamus, hippocampus, cerebral cortex, and cerebellum (in neurons rather than glia). {ECO:0000269|PubMed:12525887, ECO:0000269|PubMed:14645515, ECO:0000269|PubMed:18976727}.
Top Pathways Wnt signaling pathway

Prickle1 (F-5) - sc-393034 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Prickle1 (F-5): sc-393034. Western blot analysis of Prickle1 expression in MDA-MB-231 (A) and JAR (B) whole cell lysates and human uterus tissue extract (C).

Prickle1 (C-16) - sc-69225 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Prickle1 (C-16): sc-69225. Immunoperoxidase staining of formalin fixed, paraffin-embedded human placenta tissue showing cytoplasmic, membrane and nuclear staining of decidual cells.

Prickle1 (Y-20) - sc-69228 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-Prickle antibody - ab15577 from Abcam

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab15577 (1/50) staining Prickle in paraffin-embbeded human uterus (smooth muscle). Tissues underwent formaldehyde fixation, heat mediated antigen retrieval and peroxidase blocking prior to staining of the sections. Please refer to Abreview for further experimental details.See Abreview

Anti-Prickle antibody - C-terminal - ab139077 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Prickle antibody - C-terminal (ab139077) at 1/100 dilution + MDA-MB453 cell line lysates at 35 µgdeveloped using the ECL technique

Anti-PRICKLE1 Antibody (C-Terminus) - LS-C144447 from LifeSpan Bioscience

Prices $345.00, $1,035.00
Sizes 100 µg, 500 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of PRICKLE1 in Human Bladder cells with PRICKLE1 antibody at 20 ug/ml.

Anti-PRICKLE1 Antibody (aa678-704, Biotin) - LS-C239443 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRICKLE1 Antibody (aa678-704, AP) - LS-C239445 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRICKLE1 Antibody (aa678-704, APC) - LS-C239444 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRICKLE1 Antibody (aa678-704, FITC) - LS-C239446 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRICKLE1 Antibody (aa678-704, PE) - LS-C239447 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRICKLE1 Antibody (aa678-704, Azide-free, HRP) - LS-C248552 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRICKLE1 Antibody (aa677-704) - LS-C324288 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRICKLE1 Antibody (aa678-704) - LS-C158731 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
PRICKLE1 Antibody western blot of MDA-MB453 cell line lysates (35 ug/lane). The PRICKLE1 antibody detected the PRICKLE1 protein (arrow).

PRICKLE1 Antibody - NBP1-83967 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: PRICKLE1 Antibody [NBP1-83967] - Staining of human placenta shows strong nuclear and cytoplasmic positivity in decidua cells.

PRICKLE1 Antibody - H00144165-A01 from Novus Biologicals

Host Mouse
Clonality Polyclonal

Prickle Polyclonal Antibody - bs-12411R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Prickle Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-12411R-A350 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Prickle Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-12411R-A488 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Prickle Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-12411R-A555 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Prickle Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-12411R-A647 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Prickle Polyclonal Antibody, Cy3 Conjugated - bs-12411R-Cy3 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Prickle Polyclonal Antibody, Cy5 Conjugated - bs-12411R-Cy5 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Prickle Polyclonal Antibody, Cy5.5 Conjugated - bs-12411R-Cy5.5 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Prickle Polyclonal Antibody, Cy7 Conjugated - bs-12411R-Cy7 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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