| Gene Symbol |
PRICKLE1
|
| Entrez Gene |
144165
|
| Alt Symbol |
EPM1B, RILP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
prickle homolog 1 (Drosophila)
|
| Other Description |
REST (RE-1 silencing transcription factor)/NRSF (neuron-restrictive silencer factor)-interacting LIM domain protein|REST/NRSF-interacting LIM domain protein 1|prickle-like 1|prickle-like protein 1
|
| Swissprots |
Q14C83 Q71QF8 Q96N00 Q96MT3
|
| Accessions |
EAW57854 EAW57855 Q96MT3 AF399844 AAQ03035 AF543759 AAQ11824 AF543760 AAQ11825 AK056189 BAB71116 AK056499 BAB71198 AK122877 BAG53775 AK122881 BAG53778 BC042722 BC114939 AAI14940 BC114940 AAI14941 BE858932 CN390789 DA321918 DA413584 XM_011537946 XP_011536248 XM_011537947 XP_011536249 NM_001144881 NP_001138353 NM_001144882 NP_001138354 NM_001144883 NP_001138355 NM_153026 NP_694571
|
| Function |
Involved in the planar cell polarity pathway that controls convergent extension during gastrulation and neural tube closure. Convergent extension is a complex morphogenetic process during which cells elongate, move mediolaterally, and intercalate between neighboring cells, leading to convergence toward the mediolateral axis and extension along the anteroposterior axis. Necessary for nuclear localization of REST. May serve as nuclear receptor. {ECO:0000269|PubMed:21901791}.
|
| Subcellular Location |
Nucleus membrane {ECO:0000269|PubMed:14645515}. Cytoplasm, cytosol {ECO:0000269|PubMed:14645515}. Note=A smaller amount is detected in the cytosol.
|
| Tissue Specificity |
Expressed at highest levels in placenta and at lower levels in lung, liver, kidney and pancreas. Expressed in thalamus, hippocampus, cerebral cortex, and cerebellum (in neurons rather than glia). {ECO:0000269|PubMed:12525887, ECO:0000269|PubMed:14645515, ECO:0000269|PubMed:18976727}.
|
| Top Pathways |
Wnt signaling pathway
|
![Western Blot: PRICKLE1 Overexpression Lysate (Adult Normal) [NBL1-14754] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PRICKLE1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7407_PRICKLE1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-14754-img0002.jpg)