PRICKLE1

Gene Symbol	PRICKLE1
Entrez Gene	144165
Alt Symbol	EPM1B, RILP
Species	Human
Gene Type	protein-coding
Description	prickle homolog 1 (Drosophila)
Other Description	REST (RE-1 silencing transcription factor)/NRSF (neuron-restrictive silencer factor)-interacting LIM domain protein|REST/NRSF-interacting LIM domain protein 1|prickle-like 1|prickle-like protein 1
Swissprots	Q14C83 Q71QF8 Q96N00 Q96MT3
Accessions	EAW57854 EAW57855 Q96MT3 AF399844 AAQ03035 AF543759 AAQ11824 AF543760 AAQ11825 AK056189 BAB71116 AK056499 BAB71198 AK122877 BAG53775 AK122881 BAG53778 BC042722 BC114939 AAI14940 BC114940 AAI14941 BE858932 CN390789 DA321918 DA413584 XM_011537946 XP_011536248 XM_011537947 XP_011536249 NM_001144881 NP_001138353 NM_001144882 NP_001138354 NM_001144883 NP_001138355 NM_153026 NP_694571
Function	Involved in the planar cell polarity pathway that controls convergent extension during gastrulation and neural tube closure. Convergent extension is a complex morphogenetic process during which cells elongate, move mediolaterally, and intercalate between neighboring cells, leading to convergence toward the mediolateral axis and extension along the anteroposterior axis. Necessary for nuclear localization of REST. May serve as nuclear receptor. {ECO:0000269|PubMed:21901791}.
Subcellular Location	Nucleus membrane {ECO:0000269|PubMed:14645515}. Cytoplasm, cytosol {ECO:0000269|PubMed:14645515}. Note=A smaller amount is detected in the cytosol.
Tissue Specificity	Expressed at highest levels in placenta and at lower levels in lung, liver, kidney and pancreas. Expressed in thalamus, hippocampus, cerebral cortex, and cerebellum (in neurons rather than glia). {ECO:0000269|PubMed:12525887, ECO:0000269|PubMed:14645515, ECO:0000269|PubMed:18976727}.
Top Pathways	Wnt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Prickle protein fragment - ab153601 from Abcam Category Protein Source Wheat germ Species Human

X. laevis Prickle peptide - ab15578 from Abcam Category Peptide

PRICKLE1 Antibody Blocking Peptide - LS-E6218 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PRICKLE1 Antibody Blocking Peptide - LS-E31192 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human PRICKLE1 Protein - H00144165-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

PRICKLE1-Antibody-C-term-Blocking-Peptide - BP18864b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PRICKLE1 - H00144165-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PRICKLE1 - H00144165-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PRICKLE1 (C-term) Control Peptide - AP55573CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

PRICKLE1 Peptide - 6561P from ProSci Category Peptide Species Human

PRICKLE1 fusion protein - Ag18407 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

PRICKLE1 fusion protein - ag19573 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human PRICKLE1, GST-tagged - PRICKLE1-1943H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Prickle-like protein 1(PRICKLE1) ,partial - CSB-YP850396HU CSB-EP850396HU CSB-BP850396HU CSB-MP850396HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Prickle-like protein 1 (PRICKLE1), partial, Recombinant Protein - MBS1356729 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

PRICKLE1 Recombinant Protein Antigen - NBP1-83967PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

PRICKLE1 Peptide, Human - M34GP12378H from Creative Peptides Category Peptide Source Synthetic. Species Human

Search more