| Gene Symbol |
ERVFRD-1
|
| Entrez Gene |
405754
|
| Alt Symbol |
ERVFRDE1, GLLL6191, HERV-FRD, HERV-W/FRD, UNQ6191, envFRD
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
endogenous retrovirus group FRD, member 1
|
| Other Description |
HERV-FRD provirus ancestral Env polyprotein|HERV-FRD_6p24.1 provirus ancestral Env polyprotein|endogenous retrovirus group FRD member 1|envelope polyprotein|syncytin 2|syncytin-2
|
| Swissprots |
P60508
|
| Accessions |
CAH68778 P60508 AK075092 BAC11396 AK123938 BAC85731 AY358244 AAQ88611 BC068585 AAH68585 DA863475 GQ129285 ACT64419 GQ129286 ACT64420 NM_207582 NP_997465
|
| Function |
This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. The interaction with MFSD2A is apparently important for this process (PubMed:18988732). {ECO:0000269|PubMed:18988732}.
|
| Subcellular Location |
Virion {ECO:0000305}.
|
| Tissue Specificity |
Expressed at higher level in placenta. Expressed at lower level in adrenal, bone marrow, brain, breast, colon, kidney, lung, ovary, peripheral blood lymphocytes, prostate, skin, spleen, testis, thymus, thyroid, trachea. {ECO:0000269|PubMed:12970426}.
|